Catherine A. Lozupone
{{short description|American microbiologist}}
{{Infobox scholar
| name = Catherine A. Lozupone
| honorific_prefix =
| honorific_suffix =
| image =
| image_size =
| alt =
| caption =
| native_name =
| native_name_lang =
| pseudonym =
| birth_name = Catherine Anne Lozupone
| birth_date = {{birth year and age|1975}}
| birth_place =
| death_date =
| death_place =
| resting_place =
| era =
| region =
| workplaces = University of Colorado Denver
| alma_mater = Villanova University
Colorado State University
University of Colorado Boulder
| thesis_url =
| thesis title =
| thesis_year =
| doctoral_advisor = Rob Knight
| doctoral_students =
| notable_students =
| school_tradition =
| main_interests = microbiologist
| principal_ideas =
| major_works = Diversity, Stability and Resilience of the Human Gut Microbiota
| awards =
| influences =
| influenced =
| website =
| footnotes =
| spouse =
}}
Catherine Anne Lozupone (born 1975) is an American microbiologist who specializes in bacteria and how they impact human health. Her noted work in trying to determine what constitutes "normal" gut bacteria, led to her creation of the UniFrac algorithm, used by researchers to plot the relationships between microbial communities in the human body. Dr. Lozupone is currently at Anschutz Medical Campus School of Medicine as an associate professor.{{Cite web |title=Cathy Lozupone {{!}} Interdisciplinary Quantitative Biology {{!}} University of Colorado Boulder |url=https://www.colorado.edu/certificate/iqbiology/cathy-lozupone |access-date=2025-01-31 |website=www.colorado.edu |language=en}}
Biography
Catherine A. Lozupone earned a Bachelor of Science from Villanova University in 1997 and went on to obtain a master's degree from Colorado State University in Fort Collins, Colorado in 1999.{{sfn|Lozupone|2007|p=title}} She went on to complete her doctoral work at the University of Colorado Boulder studying under Rob Knight, who is the founder of the American Gut Project.{{cite news|last1=Pollan|first1=Michael|title=Some of My Best Friends Are Germs|url=https://www.nytimes.com/2013/05/19/magazine/say-hello-to-the-100-trillion-bacteria-that-make-up-your-microbiome.html?_r=0|access-date=9 November 2015|work=The New York Times|date=15 May 2013|location=New York City, New York}} At the time of her doctoral research, little was known about the microbiome (genes of the bacteria, archaea, microscopic eukaryotes, and viruses interacting in an environment) of the gut and the symbiotic relationship between host and bacteria. Her thesis delineated the UniFrac algorithm which has allowed researchers to visualize the relationships between microbial communities in the human gut, how they interact, and how they might be related to specific diseases.{{sfn|Knight|2015|p=89}} Lozupone's work, detailed in a 2012 paper which appeared in Nature entitled "Diversity, Stability and Resilience of the Human Gut Microbiota", was noted for its attempt to analyze what is the "normal" bacterial state in the human gut. By approaching the gut as an ecosystem, scientists are then able to factor in the effects of lifestyle, diet, health status which might change the bacterial makeup present in the gastrointestinal tract.
In 2013, after completing her post-doctoral research in Knight's lab, Lozupone started her own lab at the University of Colorado Denver, where she works in the Department of Biomedical Informatics as an associate professor. She has begun evaluating the composition differences in the microbiome of healthy individuals versus those of HIV positive individuals. She is attempting to determine if T cell loss causes change in the bacteria levels, thus prompting chronic inflammation for people living with HIV.{{cite web|title=Catherine Lozupone, PhD|url=http://www.virology-education.com/catherine-lozupone-phd/|publisher=Virology Education|access-date=9 November 2015}} According to Thomson Reuters, Lozupone was one of the most cited researchers in the world in 2014.{{cite web|title=The World's Most Influential Scientific Minds 2014|page=68|url=http://sites.biology.duke.edu/donglab/images/papers/thomas_reuter_2014.pdf|publisher=Thomson Reuters|access-date=2015-11-09|archive-url=https://web.archive.org/web/20151117020628/http://sites.biology.duke.edu/donglab/images/papers/thomas_reuter_2014.pdf|archive-date=2015-11-17|url-status=dead}} One article that may have influenced that claim is her 2012 article, "Diversity, stability and resilience of the human gut microbiota," published in Nature.{{Cite journal |last=Lozupone |first=Catherine A. |last2=Stombaugh |first2=Jesse I. |last3=Gordon |first3=Jeffrey I. |last4=Jansson |first4=Janet K. |last5=Knight |first5=Rob |date=September 2012 |title=Diversity, stability and resilience of the human gut microbiota |url=https://www.nature.com/articles/nature11550 |journal=Nature |language=en |volume=489 |issue=7415 |pages=220–230 |doi=10.1038/nature11550 |issn=1476-4687 |pmc=3577372 |pmid=22972295}} Data published by Nature show that this article ranked in the 99th percentile of nearly 200,000 articles published around the same time.{{Cite journal |title=Article Metrics - Diversity, stability and resilience of the human gut microbiota |journal=Nature |url=https://www.nature.com/articles/nature11550/metrics |language=en}}
Her most recent paper, published in 2024, provided evidence that an agrarian diet improves metabolic health of HIV positive males.{{Citation |last=Lozupone |first=Catherine |title=Agrarian Diet Improves Metabolic Health in HIV-positive Men with Prevotella-Rich Microbiomes: Results from a Randomized Trial |date=2024-11-15 |url=https://www.researchsquare.com/article/rs-5349309/v1 |access-date=2025-02-26 |doi=10.21203/rs.3.rs-5349309/v1 |last2=O'Connor |first2=John |last3=Fouquier |first3=Jennifer |last4=Neff |first4=Charles |last5=Sterrett |first5=John |last6=Marden |first6=Tyson |last7=Fiorillo |first7=Suzanne |last8=Siebert |first8=Janet |last9=Schneider |first9=Jennifer|pmc=11601827 }}
Selected work
- {{cite book|last=Lozupone|first=Catherine A. |title=Global Patterns of Bacterial Diversity|journal=Proceedings of the National Academy of Sciences of the United States of America |volume=104 |issue=27 |pages=11436–40 |url=https://books.google.com/books?id=2prF1ZotQJUC&pg=PP1|year=2007|location=Ann Arbor, Michigan|isbn=978-0-549-14062-7|pmid=17592124 |pmc=2040916 |doi=10.1073/pnas.0611525104 |ref=none|doi-access=free }}
- {{cite journal|last1=Hamady|first1=Micah|last2=Lozupone|first2=Catherine A.|last3=Knight|first3=Rob|title=Fast UniFrac: facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and PhyloChip data|journal=The ISME Journal|date=2010|volume=4|issue=1|pages=17–27|doi=10.1038/ismej.2009.97|publisher=Nature Publishing Group|location=London, England|pmid=19710709|pmc=2797552|ref=none}}
- {{cite journal|last1=Lozupone|first1=Catherine A.|last2=Stombaugh|first2=Jesse I.|last3=Gordon|first3=Jeffrey I.|last4=Jansson|first4=Janet K.|last5=Knight|first5=Rob|title=Diversity, stability and resilience of the human gut microbiota|journal=Nature|date=13 September 2012|volume=489|issue=7415|pages=220–230|doi=10.1038/nature11550|publisher=Nature Publishing Group|location=London, England|pmid=22972295|pmc=3577372|bibcode=2012Natur.489..220L|ref=none}}
References
{{Reflist|30em}}
Bibliography
- {{cite book|last=Knight|first=Rob|title=Follow Your Gut: The Enormous Impact of Tiny Microbes|url=https://books.google.com/books?id=VeBjAwAAQBAJ&pg=PT89|date=2015|publisher=Simon & Schuster/TED|isbn=978-1-4767-8475-5}}
- {{cite book|last=Lozupone|first=Catherine A. |title=Global Patterns of Bacterial Diversity|journal=Proceedings of the National Academy of Sciences of the United States of America|url=https://books.google.com/books?id=2prF1ZotQJUC&pg=PP1|year=2007|volume=104|issue=27|pages=11436–11440|location=Ann Arbor, Michigan|doi=10.1073/pnas.0611525104|isbn=978-0-549-14062-7|pmid=17592124|pmc=2040916|doi-access=free }}
External links
- [https://web.archive.org/web/20130718213448/http://live.huffingtonpost.com/r/segment/the-bugs-in-your-gut/51accfb02b8c2a4f7b0007c6 HuffPost Live interview with Catherine Lozupone]
- [https://www.worldcat.org/search?q=Catherine+A.+Lozupone&fq=ap%3A%22lozupone+catherine+a%22&dblist=638&qt=sort&se=yr&sd=asc&qt=sort_yr_asc WorldCat Publications]
- [https://web.archive.org/web/20141230223118/http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/BIPM/Faculty/Pages/Catherine-Lozupone%2C-PhD.aspx University of Colorado, extended publications list]
{{Authority control}}
{{DEFAULTSORT:Lozupone, Catherine A}}
Category:American microbiologists
Category:Villanova University alumni
Category:Colorado State University alumni
Category:University of Colorado Boulder alumni
Category:University of Colorado Denver faculty
Category:21st-century American women scientists