Cbl TKB domain

{{Infobox protein family

| Symbol = Cbl_N

| Name = CBL proto-oncogene N-terminal domain 1 (four-helix bundle)

| image = PDB 1b47 EBI.jpg

| width =

| caption = structure of the n-terminal domain of cbl in complex with its binding site in zap-70

| Pfam = PF02262

| Pfam_clan =

| InterPro = IPR003153

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1b47

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

{{Infobox protein family

| Symbol = Cbl_N2

| Name = CBL proto-oncogene N-terminus, EF hand-like domain

| image = PDB 1b47 EBI.jpg

| width =

| caption = structure of the n-terminal domain of cbl in complex with its binding site in zap-70

| Pfam = PF02761

| Pfam_clan =

| InterPro = IPR014741

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1b47

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

{{Infobox protein family

| Symbol = Cbl_N3

| Name = CBL proto-oncogene N-terminus, SH2-like domain

| image = PDB 1b47 EBI.jpg

| width =

| caption = structure of the n-terminal domain of cbl in complex with its binding site in zap-70

| Pfam = PF02762

| Pfam_clan =

| InterPro = IPR014742

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1b47

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD = cd09920

}}

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.{{cite journal | vauthors = Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ | title = Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase | journal = Nature | volume = 398 | issue = 6722 | pages = 84–90 | date = March 1999 | pmid = 10078535 | doi = 10.1038/18050 }}{{cite journal | vauthors = Langenick J, Araki T, Yamada Y, Williams JG | title = A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling | journal = Journal of Cell Science | volume = 121 | issue = Pt 21 | pages = 3524–30 | date = November 2008 | pmid = 18840649 | doi = 10.1242/jcs.036798 | doi-access = }}