Charmane Eastman

Eastman received a B.S. in mathematics with a minor in physics from SUNY Albany in 1965. Then she worked as a laboratory technician at MIT, Harvard and the University of California at Berkeley. Eventually, she attended graduate school at the University of Chicago where she earned an M.S. (1976) and Ph.D. (1980) in biological psychology. Her graduate school advisor was Allan Rechtschaffen, Her dissertation was titled “Circadian rhythms of temperature, waking, and activity in the rat: dissociations, desynchronizations, and disintegrations.”{{Cite thesis|title=Circadian rhythms of temperature, waking, and activity in the rat: dissociations, desynchronizations, and disintegrations|url=https://catalog.lib.uchicago.edu/vufind/Record/396380|date=1980|language=English|first=Charmane Ina|last=Eastman}} She then completed a post-doctoral position in the Department of Psychiatry in 1983, also in Rechtscaffen's Sleep Lab at the University of Chicago.

In 1983 Rosalind Cartwright offered Eastman a faculty position in the Psychology Department at Rush University Medical Center (RUMC), Chicago, where, in 1987, she founded and became Director of the Biological Rhythms Research Laboratory. She is currently Professor Emeritus in the Department of Psychiatry and Behavioral Sciences at RUMC.

• Spontaneous internal desynchronization. Eastman's Ph.D. dissertation included a one oscillator computer model of human circadian rhythms that explained spontaneous internal desynchronization.{{Cite journal|last=Eastman|first=C.|date=1982|editor-last=Aschoff|editor-first=Jürgen|editor2-last=Daan|editor2-first=Serge|editor3-last=Groos|editor3-first=Gerard A.|title=The Phase-Shift Model of Spontaneous Internal Desynchronization in Humans|url=https://link.springer.com/chapter/10.1007/978-3-642-68651-1_29|journal=Vertebrate Circadian Systems|series=Proceedings in Life Sciences|language=en|location=Berlin, Heidelberg|publisher=Springer|pages=262–267|doi=10.1007/978-3-642-68651-1_29|isbn=978-3-642-68651-1}} This model challenged the accepted theory that human circadian rhythms are controlled by two oscillators, one for physiological rhythms like body temperature and one for sleep and wake.{{Cite book|last=Wever|first=Rütger A.|url=https://www.worldcat.org/oclc/4498107|title=The circadian system of man : results of experiments under temporal isolation|date=1979|publisher=Springer-Verlag|isbn=0-387-90338-0|location=New York|oclc=4498107}}R. E. Kronauer, C. A. Czeisler, S. F. Pilato, M. C. Moore-Ede, and E. D. Weitzman, "Mathematical model of the human circadian system with two interacting oscillators," American Journal of Physiology, vol. 242, pp. R3-R17, 1982 Her one oscillator model C. I. Eastman, "Are separate temperature and activity oscillators necessary to explain the phenomena of human circadian rhythms?," in Mathematical Models of the Circadian Sleep-Wake Cycle, M. C. Moore-Ede and C. A. Czeisler, Eds., ed New York: Raven Press, 1984, pp. 81-103. paved the way for the current established model showing sleep controlled by a single circadian oscillator and a homeostatic component for sleep need.{{Citation|last=Daan|first=Serge|title=A History of Chronobiological Concepts|date=2010|url=http://link.springer.com/10.1007/978-1-4419-1262-6_1|work=The Circadian Clock|pages=1–35|editor-last=Albrecht|editor-first=Urs|place=New York, NY|publisher=Springer New York|language=en|doi=10.1007/978-1-4419-1262-6_1|isbn=978-1-4419-1261-9|access-date=2022-01-05}}S. Daan, D. G. Beersma, and A. A. Borbely, "Timing of human sleep: recovery process gated by a circadian pacemaker," Am J Physiol, vol. 246, pp. R161-83, Feb 1984.{{Cite journal|last1=Borbély|first1=Alexander A.|last2=Daan|first2=Serge|last3=Wirz-Justice|first3=Anna|last4=Deboer|first4=Tom|date=2016|title=The two-process model of sleep regulation: a reappraisal|journal=Journal of Sleep Research|language=en|volume=25|issue=2|pages=131–143|doi=10.1111/jsr.12371|pmid=26762182 |s2cid=206156163 |issn=1365-2869|doi-access=free}}
• Seasonal affective disorder (SAD or winter depression). Eastman developed a novel placebo treatment that she used to demonstrate the efficacy of bright light therapy for this condition.C. I. Eastman, M. A. Young, L. F. Fogg, L. Liu, and P. M. Meaden, "Bright light treatment of winter depression: A placebo-controlled trial," Archives of General Psychiatry, vol. 55, pp. 883-889, 1998.{{Cite web|title=Bright ideas help beat the blues as daylight fades|url=https://www.chicagotribune.com/news/ct-xpm-2003-10-19-0310190258-story.html|access-date=2022-01-15|website=Chicago Tribune|date=19 October 2003 |language=en}}
• NASA shuttle missions. Eastman was commissioned by NASA to create light/dark schedules for space shuttle astronauts to follow before their missions. The purpose of the schedules was to gradually shift the astronauts’ internal circadian clocks until they aligned with the shift work sleep schedules required while on orbit.K. T. Stewart and C. I. Eastman, "The light stuff: Shiftwork, circadian rhythms, and manned spaceflight," in Biologic Effects of Light 1995, M. F. Holick and E. G. Jung, Eds., ed Berlin/New York: Walter de Gruyter & Co., 1996, pp. 340-347.
• Light History. Eastman's lab demonstrated that the amount of bright light that people were exposed to in the days before a procedure could affect their sensitivity to the bright lights used in laboratory experiments and treatments.K. A. Smith, M. W. Schoen, and C. A. Czeisler, "Adaptation of human pineal melatonin suppression by recent photic history," Journal of Clinical Endocrinology and Metabolism, vol. 89, pp. 3610-3614, 2004.{{Cite journal|last1=Chang|first1=Anne-Marie|last2=Scheer|first2=Frank A. J. L.|last3=Czeisler|first3=Charles A.|date=2011-03-01|title=The human circadian system adapts to prior photic history: The human circadian system adapts to prior light history|journal=The Journal of Physiology|language=en|volume=589|issue=5|pages=1095–1102|doi=10.1113/jphysiol.2010.201194|pmc=3060589|pmid=21224217}}{{Cite journal|last1=Hébert|first1=Marc|last2=Martin|first2=Stacia K.|last3=Lee|first3=Clara|last4=Eastman|first4=Charmane I.|date=2002|title=The effects of prior light history on the suppression of melatonin by light in humans|journal=Journal of Pineal Research|language=en|volume=33|issue=4|pages=198–203|doi=10.1034/j.1600-079X.2002.01885.x|pmid=12390501 |pmc=3925650 |issn=1600-079X}}
• Dark length. Her laboratory demonstrated the dramatic effect that sleep length (dark length) has on the magnitude of circadian rhythm phase shifts that can be produced by bright light.{{Cite journal|last1=Burgess|first1=Helen J.|last2=Eastman|first2=Charmane I.|date=August 2005|title=Short Nights Attenuate Light-Induced Circadian Phase Advances in Humans|journal=The Journal of Clinical Endocrinology & Metabolism|language=en|volume=90|issue=8|pages=4437–4440|doi=10.1210/jc.2005-0536|issn=0021-972X|pmc=3841978|pmid=15886231}}
• Phase Response Curves (PRCs). Eastman devised an efficient (fewer days and less expensive) method for generating PRCs in humans. PRCs are used to determine when to apply a stimulus such as bright light exposure or melatonin to phase shift circadian rhythms, to determine when the stimulus will make circadian rhythms earlier (phase advance) or later (phase delay).{{Cite journal|last1=Revell|first1=Victoria L.|last2=Eastman|first2=Charmane I.|date=August 2005|title=How to Trick Mother Nature into Letting You Fly Around or Stay Up All Night|journal=Journal of Biological Rhythms|language=en|volume=20|issue=4|pages=353–365|doi=10.1177/0748730405277233|issn=0748-7304|pmc=3841977|pmid=16077154}}{{Cite journal|last1=Burgess|first1=Helen J.|last2=Revell|first2=Victoria L.|last3=Eastman|first3=Charmane I.|date=2008-01-15|title=A three pulse phase response curve to three milligrams of melatonin in humans: Melatonin phase response curve|journal=The Journal of Physiology|language=en|volume=586|issue=2|pages=639–647|doi=10.1113/jphysiol.2007.143180|pmc=2375577|pmid=18006583}}{{Cite journal|last=Eastman|first=Charmane|date=October 2015|title=Entraining the free-running circadian clocks of blind people|url=https://linkinghub.elsevier.com/retrieve/pii/S0140673615614519|journal=The Lancet|language=en|volume=386|issue=10005|pages=1713–1714|doi=10.1016/S0140-6736(15)61451-9|pmid=26554081 |s2cid=34870053 }}{{Cite journal|last1=Crowley|first1=Stephanie J.|last2=Eastman|first2=Charmane I.|date=August 2017|title=Human Adolescent Phase Response Curves to Bright White Light|journal=Journal of Biological Rhythms|language=en|volume=32|issue=4|pages=334–344|doi=10.1177/0748730417713423|issn=0748-7304|pmc=5972384|pmid=28651468}}
• Melatonin and bright light. Eastman's laboratory has conducted numerous studies using bright light or melatonin or the two combined to phase-shift human subjects in the laboratory.{{Cite journal|last1=Revell|first1=Victoria L.|last2=Burgess|first2=Helen J.|last3=Gazda|first3=Clifford J.|last4=Smith|first4=Mark R.|last5=Fogg|first5=Louis F.|last6=Eastman|first6=Charmane I.|date=2006-01-01|title=Advancing Human Circadian Rhythms with Afternoon Melatonin and Morning Intermittent Bright Light|url=https://paperity.org/p/89116608/advancing-human-circadian-rhythms-with-afternoon-melatonin-and-morning-intermittent|journal=The Journal of Clinical Endocrinology & Metabolism|volume=91 |issue=1|pages=54–59 |doi=10.1210/jc.2005-1009|pmid=16263827 |pmc=3841985 }} They generated phase response curves to two popular doses of melatonin which showed that for making circadian rhythms earlier (phase advances) melatonin was most effective when taken 5–7 hours before bedtime, rather than just before bedtime when most people take it. For making circadian rhythms later (phase delays), melatonin should be taken upon waking.
• Jet lag. Eastman's lab demonstrated how to start shifting circadian rhythms before flights (using bright light, sunglasses, sleep schedules and melatonin) to reduce or eliminate jet lag.{{Cite journal|last1=Eastman|first1=Charmane I.|last2=Burgess|first2=Helen J.|date=June 2009|title=How to Travel the World Without Jet Lag|journal=Sleep Medicine Clinics|language=en|volume=4|issue=2|pages=241–255|doi=10.1016/j.jsmc.2009.02.006|pmc=2829880|pmid=20204161}}R. L. Sack, D. Auckley, R. R. Auger, M. A. Carskadon, K. P. Wright, Jr., M. V. Vitiello, et al., "Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review," Sleep, vol. 30, pp. 1460-83, Nov 2007.{{Cite magazine|title=The Scientific Secrets to Preventing Jet Lag|url=https://time.com/5392876/science-cure-prevent-jet-lag/|access-date=2022-01-15|magazine=Time|language=en}}{{Cite news|last=Pollack|first=Andrew|date=2010-01-06|title=Righting the Body's Clock Through Chemicals|language=en-US|work=The New York Times|url=https://www.nytimes.com/2010/01/07/business/07jetlagbar.html|access-date=2022-01-15|issn=0362-4331}}{{Cite web|last=Miranda Hitti|title=Stopping Jet Lag Before It Starts|url=https://www.webmd.com/sleep-disorders/news/20051102/stopping-jet-lag-before-starts|access-date=2022-01-15|website=WebMD|language=en}}
• Shift work. Eastman has designed sleep and light schedules that reduce the circadian misalignment that is the basis of many of the physical and psychological harms caused by shift work.{{Cite journal|last1=Crowley|first1=Stephanie J.|last2=Lee|first2=Clara|last3=Tseng|first3=Christine Y.|last4=Fogg|first4=Louis F.|last5=Eastman|first5=Charmane I.|date=2003-12-01|title=Combinations of Bright Light, Scheduled Dark, Sunglasses, and Melatonin to Facilitate Circadian Entrainment to Night Shift Work|journal=Journal of Biological Rhythms|language=en|volume=18|issue=6|pages=513–523|doi=10.1177/0748730403258422|pmid=14667152 |s2cid=12424818 |issn=0748-7304|doi-access=free}}{{Cite journal|last1=Smith|first1=Mark R.|last2=Fogg|first2=Louis F.|last3=Eastman|first3=Charmane I.|date=November 2009|title=A Compromise Circadian Phase Position for Permanent Night Work Improves Mood, Fatigue, and Performance|journal=Sleep|language=en|volume=32|issue=11|pages=1481–1489|doi=10.1093/sleep/32.11.1481|issn=0161-8105|pmc=2768954|pmid=19928387}}{{Cite web|title=The Best Sleep Schedule for People Who Work Nights|url=https://www.oprah.com/health/best-sleep-schedule-for-people-who-work-nights|access-date=2022-01-15|website=Oprah.com}}{{Cite web|title=Sleepless on the night shift? Not just a health issue|url=https://www.cbsnews.com/news/sleepless-on-the-night-shift-its-not-just-a-health-issue/|access-date=2022-01-15|website=www.cbsnews.com|date=28 April 2015 |language=en-US}}{{Cite web|title=Light Therapy, Sunglasses May Help Shift Workers {{!}} Fox News|url=https://www.foxnews.com/story/light-therapy-sunglasses-may-help-shift-workers.amp|access-date=2022-01-15|website=www.foxnews.com}}
• Blue Light. After the discovery of the new mammalian photoreceptors in the retina (distinct from rods and cones) called intrinsically photosensitive retinal ganglion cells (ipRCGs), that are most sensitive to blue light, there was much excitement in the field. Eastman's lab generated the first phase response curve to blue light.V. L. Revell, T. A. Molina, and C. I. Eastman, "Human phase response curve to intermittent blue light using a commercially available device," J Physiol, vol. 590, pp. 4859-68, Oct 1 2012. They also compared blue-enriched white light boxes with the traditional white fluorescent light boxes and found that the traditional light boxes were already emitting enough blue light for maximal results.{{Cite journal|last1=Smith|first1=Mark R.|last2=Revell|first2=Victoria L.|last3=Eastman|first3=Charmane I.|date=March 2009|title=Phase advancing the human circadian clock with blue-enriched polychromatic light|journal=Sleep Medicine|language=en|volume=10|issue=3|pages=287–294|doi=10.1016/j.sleep.2008.05.005|pmc=2723863|pmid=18805055}}
• Racial differences in human circadian rhythms. Eastman discovered that African-Americans have shorter free-running circadian periods than European-Americans, which is an advantage in our early bird dominated society. This finding also has real-world implications with regards to shift work, jet lag, and delayed sleep phase syndrome.{{Cite journal|last1=Eastman|first1=Charmane I.|last2=Tomaka|first2=Victoria A.|last3=Crowley|first3=Stephanie J.|date=December 2016|title=Circadian rhythms of European and African-Americans after a large delay of sleep as in jet lag and night work|journal=Scientific Reports|language=en|volume=6|issue=1|pages=36716|doi=10.1038/srep36716|pmid=27819313 |pmc=5098183 |bibcode=2016NatSR...636716E |issn=2045-2322}}C. I. Eastman, V. A. Tomaka, and S. J. Crowley, "Sex and ancestry determine the free-running circadian period," Journal of Sleep Research, vol. 26, pp. 547-550, 2017.

• Baehr EK, Revelle W, Eastman CI. Individual differences in the phase and amplitude of the human circadian temperature rhythm: with an emphasis on morningness–eveningness. Journal of sleep research. 2000 Jun;9(2):117-27 [https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2869.2000.00196.x] (open access) (Cited 690 times, according to Google Scholar [https://scholar.google.com/scholar?hl=en&as_sdt=0%2C33&q=Charmane+Eastman+&btnG=] Google Scholar Author page, Accessed Jan. 9 2022)
• Eastman CI, Young MA, Fogg LF, Liu L, Meaden PM. Bright light treatment of winter depression: a placebo-controlled trial. Archives of general psychiatry. 1998 Oct 1;55(10):883-9. [https://jamanetwork.com/journals/jamapsychiatry/fullarticle/204290] (open access) (Cited 518 times, according to Google Scholar.)
• Hébert M, Martin SK, Lee C, Eastman CI. The effects of prior light history on the suppression of melatonin by light in humans. Journal of pineal research. 2002 Nov;33(4):198-203 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925650/] (open access) (Cited 475 times, according to Google Scholar.)
• Burgess HJ, Sharkey KM, Eastman CI. Bright light, dark and melatonin can promote circadian adaptation in night shift workers. Sleep medicine reviews. 2002 Oct 1;6(5):407-20. (Cited 315 times, according to Google Scholar.)
• Crowley SJ, Lee C, Tseng CY, Fogg LF, Eastman CI. Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. Journal of biological rhythms. 2003 Dec;18(6):513-23. [https://journals.sagepub.com/doi/pdf/10.1177/0748730403258422] (open access) (Cited 272 times, according to Google Scholar.)

• In 2012, she received the Excellence in Applied Circadian Rhythm Research Award from the National Sleep Foundation.{{Cite web|title=Lifetime Achievement Award|url=https://www.thensf.org/about/lifetime-achievement-award/|access-date=2022-01-10|website=National Sleep Foundation|language=en-US}}

{{reflist}}

• [https://www.rushu.rush.edu/faculty/charmane-i-eastman-phd Faculty profile, Rush University Medical Center]
• [https://www.rushu.rush.edu/research/departmental-research/behavioral-sciences-research/biological-rhythms-research-laboratory Biological Rhythms Research Laboratory]
• [https://www.ncbi.nlm.nih.gov/myncbi/charmane.eastman.1/bibliography/public/?sortby=pubDate&sdirection=descending National Library of Medicine bibliography]
• [https://academic.oup.com/sleepadvances/article/4/1/zpad040/7468162?login=false "Living Legend" article published in journal Sleep Advances]
• {{google scholar id|gildk1AAAAAJ}}

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{{DEFAULTSORT:Eastman, Charmane}}

Category:University at Albany, SUNY alumni

Category:American chronobiologists

Category:Sleep disorders

Category:University of Chicago alumni

Category:Rush University faculty

Category:Year of birth missing (living people)

Category:Living people