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Choline transporter-like protein 1

{{Short description|Mammalian protein found in Homo sapiens}}

{{cs1 config|name-list-style=vanc}}{{Infobox_gene}}

Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.{{cite journal | vauthors = Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stöckl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H | title = Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells | journal = Journal of Immunology | volume = 167 | issue = 10 | pages = 5795–5804 | date = November 2001 | pmid = 11698453 | doi = 10.4049/jimmunol.167.10.5795 | doi-access = free }}{{cite journal | vauthors = O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM | title = An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 4 | pages = 1835–40 | date = February 2000 | pmid = 10677542 | pmc = 26522 | doi = 10.1073/pnas.030339697 | bibcode = 2000PNAS...97.1835O | doi-access = free }}{{cite web | title = Entrez Gene: SLC44A1 solute carrier family 44, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23446}}

Papillary glioneuronal tumors characteristically exhibit a gene fusion between SLC44A1 and PRKCA.{{cite journal|vauthors=Bridge JA, Liu XQ, Sumegi J, Nelson M, Reyes C, Bruch LA, Rosenblum M, Puccioni MJ, Bowdiono BS, McComb RD|title=Identification of a Novel, Recurrent SLC44A1-PRKCA Fusion in Papillary Glioneuronal Tumor|volume=23|issue=2|journal=Brain Pathology|pages=121–128|doi=10.1111/j.1750-3639.2012.00612.x|pmid=22725730|pmc=8029478|doi-access=free|year=2013}}{{cite journal|journal=Acta Neuropathologica Communications|title=Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion|vauthors=Pages M, Lacroix L, Tauziede-Espariat A, Castel D, Daudigeos-Dubus E, Ridola V, Gilles S, Fina F, Andreiuolo F, Polivka M, Lechapt-Zalcman E, Puget S, Boddaert N, Liu XQ, Bridge JA, Grill J, Chretien F, Varlet P|display-authors=6|volume=3|id=85|year=2015|page=85 |doi=10.1186/s40478-015-0264-5|doi-access=free|pmid=26671581|pmc=4681033}}{{cite journal|journal=Journal of Clinical Neuroscience|title=SLC44A1 – PRKCA fusion in papillary and rosette-forming glioneuronal tumors|vauthors=Nagaishi M, Nobusawa S, Matsumura N, Kono F, Ishiuchi S, Abe T, Ebato M, Wang Y, Hyodo A, Yokoo H, Nakazato Y|year=2016|volume=23|pages=73–75|doi=10.1016/j.jocn.2015.04.021|pmid=26260115|s2cid=140207877 }} Loss of function mutations have been implicated in ethanolamine transport. {{cite journal| author=Taylor A, Grapentine S, Ichhpuniani J, Bakovic M| title=Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters. | journal=J Biol Chem | year= 2021 | volume= 296 | issue= | pages= 100604 | pmid=33789160 | doi=10.1016/j.jbc.2021.100604 | pmc=8081925 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33789160 }}

See also

References

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Further reading

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  • {{cite journal | vauthors = Yuan Z, Tie A, Tarnopolsky M, Bakovic M | title = Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1 | journal = Physiological Genomics | volume = 26 | issue = 1 | pages = 76–90 | date = June 2006 | pmid = 16609143 | doi = 10.1152/physiolgenomics.00107.2005 | s2cid = 8181779 | url = http://pdfs.semanticscholar.org/be7f/cbc1922b5ddee36c3a001c6751094a454278.pdf | archive-url = https://web.archive.org/web/20190304013050/http://pdfs.semanticscholar.org/be7f/cbc1922b5ddee36c3a001c6751094a454278.pdf | url-status = dead | archive-date = 2019-03-04 }}
  • {{cite journal | vauthors = Fullerton MD, Wagner L, Yuan Z, Bakovic M | title = Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages | journal = American Journal of Physiology. Cell Physiology | volume = 290 | issue = 4 | pages = C1230–C1238 | date = April 2006 | pmid = 16319125 | doi = 10.1152/ajpcell.00255.2005 | s2cid = 5096497 | url = http://pdfs.semanticscholar.org/3827/9b6d758fe551836f6385ebe587a312abaaa6.pdf | archive-url = https://web.archive.org/web/20190222031805/http://pdfs.semanticscholar.org/3827/9b6d758fe551836f6385ebe587a312abaaa6.pdf | url-status = dead | archive-date = 2019-02-22 }}
  • {{cite journal | vauthors = Li D, Wang F, Lai M, Chen Y, Zhang JF | title = A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C | journal = The Journal of Neuroscience | volume = 25 | issue = 8 | pages = 1914–23 | date = February 2005 | pmid = 15728831 | doi = 10.1523/JNEUROSCI.4790-04.2005 | pmc = 6726054 | doi-access = free }}
  • {{cite journal | vauthors = Traiffort E, Ruat M, O'Regan S, Meunier FM | title = Molecular characterization of the family of choline transporter-like proteins and their splice variants | journal = Journal of Neurochemistry | volume = 92 | issue = 5 | pages = 1116–25 | date = March 2005 | pmid = 15715662 | doi = 10.1111/j.1471-4159.2004.02962.x | s2cid = 30921826 | doi-access = free }}
  • {{cite journal | vauthors = Lecomte MJ, De Gois S, Guerci A, Ravassard P, Faucon Biguet N, Mallet J, Berrard S | title = Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia | journal = Molecular and Cellular Neurosciences | volume = 28 | issue = 2 | pages = 303–13 | date = February 2005 | pmid = 15691711 | doi = 10.1016/j.mcn.2004.09.014 | s2cid = 20828310 }}
  • {{cite journal | vauthors = Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P | title = Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 26 | pages = 16006–11 | date = December 2003 | pmid = 14663150 | pmc = 307683 | doi = 10.1073/pnas.2136600100 | bibcode = 2003PNAS..10016006F | doi-access = free }}
  • {{cite journal | vauthors = Takekawa M, Maeda T, Saito H | title = Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways | journal = The EMBO Journal | volume = 17 | issue = 16 | pages = 4744–52 | date = August 1998 | pmid = 9707433 | pmc = 1170803 | doi = 10.1093/emboj/17.16.4744 }}

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External links

  • {{MeshName|SLC44A1+protein,+human}}

{{Clusters of differentiation}}

{{Membrane transport proteins}}

Category:Solute carrier family

Category:Clusters of differentiation

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