Christian Hartinger

{{Short description|New Zealand bioinorganic chemist known for his work in metal-based anticancer drugs}}

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{{Infobox scientist

| honorific_prefix =

| name = Christian Hartinger

| honorific_suffix = {{post-nominals|country=NZL|FRSNZ|size=100%}}

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| caption = Christian Hartinger

| birth_date = {{Birth year and age|1974}}

| birth_place = Vienna, Austria

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| nationality = Austrian

| fields = Chemistry

| work_institutions = University of Auckland

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| alma_mater = University of Vienna (MSc, 1999; PhD, 2001; Habilitation, 2009)

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| doctoral_advisor = Bernhard Keppler

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| awards = New Zealand Institute of Chemistry Maurice Wilkins Centre Prize

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| website = {{URL|hartinger.auckland.ac.nz/}}

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Christian G. Hartinger {{Post-nominals|country=NZL|FRSNZ}} (born 1974) is an Austrian-born New Zealand bioinorganic chemist known for his work in metal-based anticancer drugs. In 2022 he was elected a Fellow of the Royal Society Te Apārangi.

Scientific career

Hartinger studied chemistry at the University of Vienna, earning his MSc in 1999 and his PhD in 2001 under Bernhard Keppler. He was an Erwin Schrödinger Fellow with Paul Dyson at the École Polytechnique Fédérale de Lausanne from 2006 to 2008 and obtained his habilitation at the University of Vienna in 2009. In 2011, Hartinger was appointed the position of associate professor at Waipapa Taumata Rau, where he currently serves and in 2015 was promoted to professor.

Hartinger's research interests are in bioinorganic chemistry, medicinal chemistry, and bioanalytical chemistry, where he uses an interdisciplinary approach in drug discovery. He is specially interested in the development of metal-centred anticancer agents, particularly ruthenium anticancer drugs, and using analytical methods to characterise their behaviour in the presence of biomolecules.

{{cite journal

| title = Antitumour metal compounds: more than theme and variations

|author1=Jakupec, M. A. |author2=Galanski, M. |author3=Arion, V. B. |author4=Hartinger, C. G. |author5= Keppler, B. K. |name-list-style=amp | journal = Dalton Transactions

| issue = 2

| pages = 183–194 | year = 2008

| doi = 10.1039/b712656p

|pmid=18097483 |url=https://phaidra.univie.ac.at/o:243577 }}

Hartinger has now published over 169 publications and has an h-index of 69.{{cite web

| url = https://scholar.google.co.nz/citations?user=GZ7ff3cAAAAJ

| title = Christian Hartinger's Google Scholar profile

| website =

| access-date = 10 March 2017

}}{{Dead link|date=July 2020 |bot=InternetArchiveBot |fix-attempted=yes }}

In 2022 Hartinger was elected a Fellow of the Royal Society Te Apārangi. The society said his "innovative approaches have established new directions in metallodrug research, and his developed methodologies continue to have far-reaching impact in the community. His findings challenge paradigms about the reactivity of metal compounds towards biomolecules and thereby inform the design of novel biomaterials".{{Cite web |title=Researchers and scholars at the top of their fields elected as Fellows |url=https://www.royalsociety.org.nz/news/researchers-and-scholars-at-the-top-of-their-fields-elected-as-fellows-2021/ |access-date=2022-03-18 |website=Royal Society Te Apārangi}}

Distinctions/honours

class="wikitable sortable"
YearDistinction/honourOrganisation
2005Theodor Körner PrizeTheodor Körner Fund
2006Erwin Schrödinger FellowshipAustrian Science Fund
2009Best Paper Award for the publication "Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity"

{{cite journal

| title = Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity

|author1=Mendoza-Ferri, M. G. |author2=Hartinger, C. G. |author3=Alexey, A. A. |author4=Kandioller, W. |author5=Severin, K. |author6= Keppler, B. K. |name-list-style=amp | journal = Applied Organometallic Chemistry

| volume = 22

| issue = 6

| pages = 326–332 | year = 2008

| doi = 10.1002/aoc.1394

}}

Applied Organometallic Chemistry
rowspan="2" | 2010Innovative Teaching AwardBank Austria
Visiting ProfessorChimie ParisTech, France
2011Carl Duisberg Memorial PrizeGerman Chemical Society
2013

|Visiting Professor

|University of Vienna

2014Scientific Organizing Committee Co-chair7th International Symposium on Bioorganometallic Chemistry
2016Chair of the 8th Asian Biological Inorganic Chemistry Conference8th Asian Biological Inorganic Chemistry (AsBIC) Conference
2016SBIC Early Career Award 2016[http://sbichem.org/ Society of Biological Inorganic Chemistry]
2016New Zealand Institute of Chemistry Maurice Wilkins Centre Prize[http://www.mauricewilkinscentre.org/ Maurice Wilkins Centre]
2017Hood Fellowship (Cambridge, UK)[https://web.archive.org/web/20170212162317/http://uoafoundation.org.nz/hood.html The University of Auckland Foundation]
2017

|Hill Tinsley Medal

|New Zealand Association of Scientists

Selected research outputs

  • Meier, S. M.; Novak, M. S.; Kandioller, W.; Jakupec, M. A.; Roller, A.; Keppler, B. K.; Hartinger, C. G., Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent. Dalton Trans, 2014, 43 (26), 9851–9855
  • Meier, S. M.; Babak, M. V.; Keppler, B. K.; Hartinger, C. G., Efficiently detecting metallodrug-protein adducts: ion trap versus time-of-flight mass analyzers. ChemMedChem, 2014, 9 (7), 1351–1355
  • Hartinger, C. G.; Groessl, M.; Meier, S. M.; Casini, A.; Dyson, P. J., Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs. Chem Soc Rev, 2013, 42 (14), 6186–6199
  • Meier, S. M.; Novak, M.; Kandioller, W.; Jakupec, M. A.; Arion, V. B.; Metzler-Nolte, N.; Keppler, B. K.; Hartinger, C. G., Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate. Chem Eur J, 2013, 19 (28), 9297–9307
  • Kandioller, W.; Balsano, E.; Meier, S. M.; Jungwirth, U.; Göschl S.; Roller, A.; Jakupec, M. A.; Berger, W.; Keppler, B. K.; Hartinger, C. G., Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chem Commun, 2013, 49 (32), 3348–3350
  • Meier, S. M.; Hanif, M.; Pichler, V.; Novak, M.; Jirkovsky, E.; Jakupec, M. A.; Davey, C. A.; Keppler, B. K.; Hartinger, C. G., Novel metal(II) arene 2-pyridinecarbothioamides: A rationale to orally active organometallic anticancer agents. Chem Sci, 2013, 4 (4), 1837–1846
  • Babak, M. V.; Meier, S. M.; Legin, A. A.; Adib Razavi, M. S.; Roller, A.; Jakupec, M. A.; Keppler, B. K.; Hartinger, C. G., Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development. Chemistry, 2013, 19 (13), 4308–4318
  • Kurzwernhart, A.; Kandioller, W.; Bächler S.; Bartel, C.; Martic, S.; Buczkowska, M.; Mühlgassner, G.; Jakupec, M. A.; Kraatz, H.; Berdnarski, P. J.; Arion, V. B.; Markos, D.; Keppler, B. K.; Hartinger, C. G., Structure-activity relationships of targeted RuII6-p-cymene) anticancer complexes with flavonol-derived ligands. J Med Chem, 2012, 55 (23), 10512-10522

References

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