Christopher Burge
{{Short description|American scientist}}{{Infobox scientist
| name = Chris Burge
| birth_name = Christopher Boyce Burge
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| caption = Do you have a picture of Christopher Burge? Please, post here.
| birth_date = {{Birth date and age|1968|05|26}}http://genes.mit.edu/burgelab/CBurgeCV.pdf {{Webarchive|url=https://web.archive.org/web/20110817033046/http://genes.mit.edu/burgelab/CBurgeCV.pdf |date=2011-08-17 }} Christopher Burge CV
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| workplaces = Massachusetts Institute of Technology
| alma_mater = Stanford University
| doctoral_advisor = Samuel Karlin{{MathGenealogy|id=144001}}
| thesis_title = Identification of genes in human genomic DNA
| thesis_url =https://www.proquest.com/docview/304386368
| thesis_year = 1997
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| known_for = GENSCAN{{Cite journal
| last1 = Burge
| first1 = Christopher
| author-link1 = Christopher Burge
| last2 = Karlin
| first2 = Samuel
| author-link2 = Samuel Karlin
| title = Prediction of complete gene structures in human genomic DNA
| doi = 10.1006/jmbi.1997.0951
| journal = Journal of Molecular Biology
| volume = 268
| issue = 1
| pages = 78–94
| year = 1997
| pmid = 9149143
| url = https://ai.stanford.edu/~serafim/cs262/Papers/GENSCAN.pdf
| url-status = dead
| archive-url = https://web.archive.org/web/20150620094015/https://ai.stanford.edu/~serafim/cs262/Papers/GENSCAN.pdf
| archive-date = 2015-06-20
| doi = 10.1016/S0959-440X(98)80069-9
| last1 = Burge
| first1 = C.
| author-link1 = Christopher Burge
| last2 = Karlin
| first2 = S.
| author-link2 = Samuel Karlin
| title = Finding the genes in genomic DNA
| journal = Current Opinion in Structural Biology
| volume = 8
| issue = 3
| pages = 346–354
| year = 1998
| url =
| pmid = 9666331
| doi-access = free
}}
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| awards = Overton Prize{{cite web |title=Overton Prize |url=https://www.iscb.org/iscb-awards/overton-prize |website=www.iscb.org |access-date=23 May 2021}}
Searle Scholar Award{{cite web|title=Searle Scholars Program: Christopher Burge (2003)|url=http://www.searlescholars.net/person/79|access-date=10 August 2015|archive-url=https://web.archive.org/web/20150905090131/http://www.searlescholars.net/person/79|archive-date=5 September 2015|url-status=dead}}
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| website = {{URL|http://genes.mit.edu/burgelab/cburge.html}}
}}Christopher Boyce Burge is an American computational biologist and a Professor of Biology and Biological Engineering at Massachusetts Institute of Technology. He is known for his research on gene expression regulation, particularly RNA processing mechanisms like RNA splicing, polyadenylation, and microRNA-mediated regulation, using computational and experimental approaches.{{Cite web |title=Christopher Burge |url=https://biology.mit.edu/profile/christopher-burge/ |access-date=2025-04-17 |website=MIT Department of Biology |language=en-US}}{{Cite web |title=Chris |url=https://www.genes.mit.edu/chris |access-date=2025-04-17 |website=Christopher Burge Laboratory |language=en-US}}
Education
Burge completed his Bachelor of Science at Stanford University in 1990, and continued graduate studies in computational biology at Stanford University, gaining his PhD{{cite thesis |degree=PhD |first=Christopher Boyce|last=Burge |title=Identification of genes in human genomic DNA |publisher=Stanford University |date=2012 |author-link=Christopher Burge|id={{ProQuest|304386368}}}} in 1997 under the supervision of Samuel Karlin. During his time at Stanford he was responsible for developing algorithms for GENSCAN used in gene prediction for example the initial analysis of the Human Genome Project.{{Cite journal | first1 = E. S.| last1 = Lander| author-link1 = Eric Lander| last2 = Linton | first2 = M. | last3 = Birren | first3 = B. | last4 = Nusbaum | first4 = C. | last5 = Zody | first5 = C.| last6 = Baldwin | first6 = J. | last7 = Devon | first7 = K. | last8 = Dewar | first8 = K. | last9 = Doyle | first9 = M. | last10 = Fitzhugh | first10 = W. | last11 = Funke | first11 = R. | last12 = Gage | first12 = D. | last13 = Harris | first13 = K. | last14 = Heaford | first14 = A. | last15 = Howland | first15 = J. | last16 = Kann | first16 = L. | last17 = Lehoczky | first17 = J. | last18 = Levine | first18 = R. | last19 = McEwan | first19 = P. | last20 = McKernan | first20 = K. | last21 = Meldrim | first21 = J. | last22 = Mesirov | first22 = J. P. | last23 = Miranda | first23 = C. | last24 = Morris | first24 = W. | last25 = Naylor | first25 = J. | last26 = Raymond | first26 = C. | last27 = Rosetti | first27 = M. | last28 = Santos | first28 = R. | last29 = Sheridan | first29 = A. | last30 = Sougnez | first30 = C. | display-authors = 29| title = Initial sequencing and analysis of the human genome | journal = Nature | volume = 409 | issue = 6822 | pages = 860–921 | date =Feb 2001 | issn = 0028-0836 | pmid = 11237011 | doi = 10.1038/35057062| bibcode = 2001Natur.409..860L| url = https://deepblue.lib.umich.edu/bitstream/2027.42/62798/1/409860a0.pdf | doi-access = free }} His PhD thesis was titled Identification of genes in human genomic DNA.
Research
From 1997 to 1999 Burge worked as a postdoc in the laboratory of Phillip Allen Sharp, working in the fields of RNA splicing and molecular evolution.{{Cite journal
| last1 = Burge | first1 = C.
| last2 = Padgett | first2 = R.
| last3 = Sharp | first3 = P.
| title = Evolutionary fates and origins of U12-type introns
| journal = Molecular Cell
| volume = 2
| issue = 6
| pages = 773–785
| year = 1998
| pmid = 9885565
| doi = 10.1016/S1097-2765(00)80292-0
| doi-access = free
}} Burge joined the Massachusetts Institute of Technology in 1999 as a Bioinformatics Fellow. He became Assistant Professor in 2002, Associate Professor in 2004, was tenured in 2006, and was promoted to full Professor in 2010. He has been an Associate Member of the Broad Institute since 2004. His current research interests include genomics, RNA splicing and microRNA{{Cite journal | last1 = Rhoades | first1 = M. W. | last2 = Reinhart | first2 = B. J. | last3 = Lim | first3 = L. P. | last4 = Burge | first4 = C. B. | last5 = Bartel | first5 = B. | last6 = Bartel | first6 = D. P. | doi = 10.1016/S0092-8674(02)00863-2 | title = Prediction of Plant MicroRNA Targets | journal = Cell | volume = 110 | issue = 4 | pages = 513–520 | year = 2002 | pmid = 12202040| doi-access = free }} regulation.{{Scopus|id=7004110326}}http://www.biomedexperts.com/Profile.bme/172484/Christopher_B_Burge {{Webarchive|url=https://web.archive.org/web/20120321235706/http://www.biomedexperts.com/Profile.bme/172484/Christopher_B_Burge|date=2012-03-21}} Chris Burge profile in BiomedExperts{{Cite journal | doi = 10.1016/j.cell.2004.12.035| pmid = 15652477| title = Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets| journal = Cell| volume = 120| issue = 1| pages = 15–20| year = 2005| last1 = Lewis | first1 = B. P. | last2 = Burge | first2 = C. B. | last3 = Bartel | first3 = D. P. | doi-access = free}}{{Cite journal | doi = 10.1016/S0092-8674(03)01018-3| pmid = 14697198| title = Prediction of Mammalian MicroRNA Targets| journal = Cell| volume = 115| issue = 7| pages = 787–98| year = 2003| last1 = Lewis | first1 = B. P. | last2 = Shih | first2 = I. H. | last3 = Jones-Rhoades | first3 = M. W. | last4 = Bartel | first4 = D. P. | last5 = Burge | first5 = C. B. | doi-access = free }}
Burge has also served on the editorial boards of the academic journals RNA, PLOS Computational Biology, BMC Bioinformatics and ''BMC Genomics.
Awards
In 2001 he was awarded the Overton Prize for Computational Biology by the International Society for Computational Biology. He was awarded a Searle Scholar Award in 2003 for his research in the computational biology of gene expression. In 2007 he was awarded the Schering-Plough Research Institute Award (now known as the ASBMB Young Investigator Award) by the American Society for Biochemistry and Molecular Biology for his outstanding research contributions to biochemistry and molecular biology.{{cite web|title=ASBMB Young Investigator Award formerly the ASBMB Schering-Plough Research Institute Award|url=http://www.asbmb.org/Page.aspx?id=510|access-date=10 August 2015}}
References
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Category:Stanford University alumni
Category:Overton Prize winners
Category:Massachusetts Institute of Technology faculty
Category:American bioinformaticians