Class II PI 3-kinases

Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

PI3K-C2α encoded by the PIK3C2A gene
PI3K-C2β encoded by the PIK3C2B gene
PI3K-C2γ encoded by the PIK3C2G gene

References

{{cite journal | vauthors = Stein RC | title = Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment | journal = Endocrine-Related Cancer | volume = 8 | issue = 3 | pages = 237–248 | date = September 2001 | pmid = 11566615 | doi = 10.1677/erc.0.0080237 }}
{{cite journal | vauthors = Foster FM, Traer CJ, Abraham SM, Fry MJ | title = The phosphoinositide (PI) 3-kinase family | journal = Journal of Cell Science | volume = 116 | issue = Pt 15 | pages = 3037–3040 | date = August 2003 | pmid = 12829733 | doi = 10.1242/jcs.00609 }}
{{cite journal | vauthors = Vanhaesebroeck B, Waterfield MD | title = Signaling by distinct classes of phosphoinositide 3-kinases | journal = Experimental Cell Research | volume = 253 | issue = 1 | pages = 239–254 | date = November 1999 | pmid = 10579926 | doi = 10.1006/excr.1999.4701 }}

Category:EC 2.7.1

Class II PI 3-kinases

See also

References