Claudia Fischbach
{{Short description|German biophysicist}}
{{Use dmy dates|date=January 2023}}{{Infobox scientist
| name = Claudia Fischbach
| workplaces = Cornell University
Harvard University
| alma_mater = University of Regensburg
Harvard University
| thesis_title = Adipose tissue engineering development of a 3-D model system of adipogenesis.
| thesis_url = https://worldcat.org/en/title/1184086148
| thesis_year = 2004
}}
Claudia Fischbach is a German bioengineer who serves as the James M. and Marsha McCormick Director of Biomedical Engineering and the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University. She is Director of the Cornell Physical Sciences Oncology Center on the Physics of Cancer Metabolism.
Early life and education
Fischbach earned a master's degree in pharmacy from the Ludwig Maximilian University of Munich. She worked toward her doctorate in pharmaceutical technology at the University of Regensburg. She then moved to Harvard University, where she worked in tissue engineering.{{Cite web |title=Claudia Fischbach |url=https://mooneylab.seas.harvard.edu/people/claudia-fischbach |access-date=2023-01-06 |website=mooneylab.seas.harvard.edu |language=en}}
Research and career
In 2007, Fischbach joined Cornell University,{{Cite web |title=Principal Investigator – THE FISCHBACH LAB |url=https://www.fischbachlab.org/principal-investigator/ |access-date=2023-01-06 |website=www.fischbachlab.org}} where she started using biomedical engineering to better understand how to treat cancer.{{Cite web |title=Research – THE FISCHBACH LAB |url=https://www.fischbachlab.org/research/ |access-date=2023-01-06 |website=www.fischbachlab.org}} The progression of cancer is influenced by interactions with nearby cells and the extracellular matrix. Despite that, the majority of cancer studies do not replicate conditions outside of the body. Fischbach uses tissue engineering to design systems that let her lab model and investigate how these interactions influence tumor cells. She uses model systems to understand the biological strategies tumors adopt to modify bodily function, become more aggressive, and metastasize.{{Cite web |title=Claudia Fischbach {{!}} Cornell Engineering |url=https://www.engineering.cornell.edu/faculty-directory/claudia-fischbach |access-date=2023-01-06 |website=www.engineering.cornell.edu |language=en}}
Fischbach has extensively investigated the fundamental mechanisms that underpin breast cancer. For example, she showed that obesity can change the composition of breast tissue, which can promote disease progression.{{Cite web |title=Stiffer breast tissue in obese women promotes tumors |url=https://news.cornell.edu/stories/2015/08/stiffer-breast-tissue-obese-women-promotes-tumors |access-date=2023-01-06 |website=Cornell Chronicle |language=en}}{{Cite web |last=Ramanujan-Cornell |first=Krishna |date=2015-08-25 |title=Obesity makes breast tissue stiff and scarred |url=https://www.futurity.org/obesity-breast-cancer-989012/ |access-date=2023-01-06 |website=Futurity |language=en-US}} Moreover, she was supported by the Human Frontier Science Program to study the impact of breast cancer on the material properties of bone.{{Cite web |title=Study to focus on breast cancer's effect on bone composition |url=https://news.cornell.edu/stories/2017/03/study-focus-breast-cancers-effect-bone-composition |access-date=2023-01-06 |website=Cornell Chronicle |language=en}}{{Cite web |title=Metastatic breast cancer affects bone mineral before spreading |url=https://news.cornell.edu/stories/2017/09/metastatic-breast-cancer-affects-bone-mineral-spreading |access-date=2023-01-06 |website=Cornell Chronicle |language=en}} She showed that exercise, which is often prescribed to prevent bone loss, could also help to protect people against metastatic cancer.{{Cite web |title=Exercise could reduce bone tumor growth |url=https://news.cornell.edu/stories/2013/05/exercise-could-reduce-bone-tumor-growth |access-date=2023-01-06 |website=Cornell Chronicle |language=en}} In addition, her research demonstrated that breast cancer can trigger distant bone growth, which could be a preemptive defense against metastasis.{{Cite web |title=Researchers link breast cancer and bone growth |url=https://news.cornell.edu/stories/2021/03/researchers-link-breast-cancer-and-bone-growth |access-date=2023-01-06 |website=Cornell Chronicle |language=en}}
Awards and honors
- 2015 Public Voices Fellow of The OpEd Project{{Cite web |title=Stories by Claudia Fischbach |url=https://www.scientificamerican.com/claudia-fischbach/ |access-date=2023-01-06 |website=Scientific American |language=en}}
- 2016 Fellow of the American Institute for Medical and Biological Engineering{{Cite web |title=Claudia Fischbach-Teschl Claudia Fischbach-Teschl, Ph.D. To be Inducted into Medical and Biological Engineering Elite - AIMBE |url=https://aimbe.org/claudia-fischbach-teschl-ph-d-to-be-inducted-into-medical-and-biological-engineering-elite/ |access-date=2023-01-06 |language=en}}{{Cite web |title=Claudia Fischbach-Teschl, Ph.D. COF-1951 - AIMBE |url=https://aimbe.org/college-of-fellows/cof-1951/ |access-date=2023-01-06 |language=en}}
- 2017 Alexander von Humboldt Foundation{{Cite web |title=Prof. Dr. Claudia Fischbach-Teschl - Alexander von Humboldt-Stiftung |url=https://www.humboldt-foundation.de/en/connect/explore-the-humboldt-network/singleview?tx_rsmavhsolr_solrview%5BpPersonId%5D=1152037&cHash=9efdd36afec1a3e0fca8d4ec41e92f51}}
- 2018 Fellow of the Biomedical Engineering Society
- 2022 Cornell University College of Engineering EPICC Award{{Cite web |title=EPICC Awards honor faculty, staff exemplifying college's core values {{!}} Cornell Engineering |url=https://www.engineering.cornell.edu/news/epicc-awards-honor-faculty-staff-exemplifying-colleges-core-values |access-date=2023-01-06 |website=www.engineering.cornell.edu}}
- 2023 Biomedical Engineering Society Cellular and Molecular Bioengineering Momentum Award{{Cite web |title=Claudia Fischbach-Teschl wins 2023 CMBE Momentum Award {{!}} Meinig School of Biomedical Engineering |url=https://www.bme.cornell.edu/news/claudia-fischbach-teschl-wins-2023-cmbe-momentum-award |access-date=2023-01-06 |website=www.bme.cornell.edu}}{{Cite web |title=CMBE Momentum Award - Biomedical Engineering Society |url=https://www.bmes.org/momentum-award |access-date=2023-01-06 |website=www.bmes.org}}
Selected publications
- Siyoung Choi, Matthew A Whitman, Adrian A Shimpi, ... Claudia Fischbach (7 August 2023). [https://pubmed.ncbi.nlm.nih.gov/37550422/ "Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer."] Nature Biomedical Engineering. PMID 37550422.
- Bo Ri Seo, Xingyu Chen, Lu Ling, ... Claudia Fischbach (8 May 2020). [https://pubmed.ncbi.nlm.nih.gov/32385149/ "Collagen microarchitecture mechanically controls myofibroblast differentiation."] Proceedings of the National Academy of Sciences. PMID 32385149.
- Bo Ri Seo, Priya Bhardwaj, Siyoung Choi ... Claudia Fischbach (19 August 2015). [https://pubmed.ncbi.nlm.nih.gov/26290412/ "Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis."] Science Translational Medicine. PMID 26290412.
- Maureen E Lynch, Daniel Brooks, Sunish Mohanan, ... Claudia Fischbach (3 May 2013). [https://pubmed.ncbi.nlm.nih.gov/23649605/ "In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model."] Journal of Bone and Mineral Research. PMID 23649605.
- Claudia Fischbach, Hyun Joon Kong, Susan X Hsiong, ... David J Mooney (6 January 2009). [https://pubmed.ncbi.nlm.nih.gov/19126683/ "Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement."] Proceedings of the National Academy of Sciences. PMID 19126683.
References
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Category:Year of birth missing (living people)
Category:21st-century German biologists
Category:21st-century German physicists
Category:21st-century German women scientists
Category:Ludwig Maximilian University of Munich alumni
Category:University of Regensburg alumni
Category:German emigrants to the United States