Clocental
{{Short description|Chemical compound}}
{{Distinguish|Placental}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Drugbox
| Verifiedfields =
| Watchedfields =
| verifiedrevid =
| IUPAC_name = (1-Ethynylcyclohexyl) N-carbamoylcarbamate
| synonyms = Dolcental
| image = Clocental.svg
| image_class = skin-invert-image
| alt = Structural formula
| image2 = Clocental molecule ball.png
| alt2 = Ball-and-stick model of the clocental molecule
| width = 200
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| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 562-94-7
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = UX2C2JZD57
| ATC_prefix =
| ATC_suffix =
| PubChem = 11231
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10757
| ChEMBL_Ref = {{ebicite|correct|EBI}}
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| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG =
| C=10 | H=14 | N=2 | O=3
| smiles = C#CC1(CCCCC1)OC(=O)NC(=O)N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H14N2O3/c1-2-10(6-4-3-5-7-10)15-9(14)12-8(11)13/h1H,3-7H2,(H3,11,12,13,14)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = CQVLNDZXTPGTFD-UHFFFAOYSA-N
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Clocental (dolcental) is a carbamate-derived sedative hypnotic.{{cite journal | vauthors = Keil W, Muschaweck R, Rademacher E | title = [Sedative and hypnotic effect of the 1-ethinyl-cyclohexyl-allophante-(1)] | language = DE | journal = Arzneimittel-Forschung | volume = 4 | issue = 8 | pages = 477–479 | date = August 1954 | pmid = 13198744 }}{{cite journal | vauthors = Preuss R, Kopp R | title = [Analysis of the renal excretion products of 1-ethinyl-cyclohexylacarbamate (valamine) & 1-ethinyl-cyclohexyl-allophanate (dolcental)] | language = DE | journal = Arzneimittel-Forschung | volume = 9 | issue = 4 | pages = 255–262 | date = April 1959 | pmid = 13651050 }}
Synthesis
Clocental was first prepared by the acylation of 1-ethynylcyclohexanol with allophanyl chloride.{{cite patent |country=US |number=2822379 |inventor = Grimme W, Emde H |title=Allophanates of alpha-ethynylcarbinols |status=patent |gdate=1958-02-04 |fdate=1954-09-10 |assign1=Rheinpreussen AG fuer Bergbau und Chemie}}
See also
References
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{{sedative-stub}}
{{Hypnotics and sedatives}}
{{GABAAR PAMs}}