Cloxestradiol

{{Short description|Chemical compound}}

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| IUPAC_name = (8R,9S,13S,14S,17S)-13-methyl-17-(2,2,2-trichloro-1-hydroxyethoxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol

| image = Cloxestradiol.svg

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| class = Estrogen; Estrogen ether

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| CAS_number = 54063-33-1

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| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 42R9MZG1DL

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| PubChem = 194705

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| ChemSpiderID = 168924

| synonyms = 17-(2,2,2-Trichloroethoxy)estradiol; 17-(1-Hydroxy-2,2,2-trichloroethoxy)estra-1,3,5(10-trien-3-ol

| C=20 | H=25 | Cl=3 | O=3

| SMILES = C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2OC(C(Cl)(Cl)Cl)O)O

| StdInChI = 1S/C20H25Cl3O3/c1-19-9-8-14-13-5-3-12(24)10-11(13)2-4-15(14)16(19)6-7-17(19)26-18(25)20(21,22)23/h3,5,10,14-18,24-25H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18?,19+/m1/s1

| StdInChIKey = JVLHMVXGPLKLFV-AJUWMHLFSA-N

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Cloxestradiol ({{abbrlink|INN|International Nonproprietary Name}}), also known as 17-(2,2,2-trichloroethoxy)estradiol, is a synthetic, steroidal estrogen which was never marketed.{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA308|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=308–}} It is an analogue of estradiol with a 2,2,2-trichloroethoxy substitution. The O,O-diacetate derivative, cloxestradiol acetate (brand name Genovul), has been marketed as an estrogen.