Codeinone reductase (NADPH)

{{infobox enzyme

| Name = codeinone reductase (NADPH)

| EC_number = 1.1.1.247

| CAS_number = 153302-41-1

| GO_code = 0047036

| image =

| width =

| caption =

}}

In enzymology, a codeinone reductase (NADPH) ({{EC number|1.1.1.247}}) is an enzyme that catalyzes the chemical reaction

:codeine + NADP⁺ $\rightleftharpoons$ codeinone + NADPH + H⁺

Thus, the two substrates of this enzyme are codeine and NADP⁺, whereas its 3 products are codeinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is codeine:NADP⁺ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

References

{{cite journal |author1 = Lenz R |author2 =Zenk MH | date = 1995 | title = Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum | journal = Tetrahedron Lett. | volume = 36 | pages = 2449–2452 | doi = 10.1016/0040-4039(95)00278-K | issue = 14 }}
{{cite journal | vauthors = Lenz R, Zenk MH | date = 1995 | title = Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants | journal = Eur. J. Biochem. | volume = 233 | pages = 132–9 | pmid = 7588736 | doi = 10.1111/j.1432-1033.1995.132_1.x | issue = 1 | doi-access = free }}

Category:EC 1.1.1

Category:NADPH-dependent enzymes

Category:Enzymes of unknown structure