Colestipol

{{short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 477514682

| IUPAC_name = Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane

| image = Colestipol skeletal 2.svg

| tradename = Colestid, Cholestabyl

| Drugs.com = {{drugs.com|monograph|colestipol-hydrochloride}}

| MedlinePlus = a682157

| pregnancy_AU =

| pregnancy_US = B

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US = Rx-only

| legal_status =

| routes_of_administration = Oral (suspension or tablets)

| bioavailability = None

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion = Faeces, in complex with bile acids

| CAS_number_Ref = {{cascite|changed|CAS}}

| CAS_number = 26658-42-4

| CAS_supplemental =
{{CAS|37296-80-3}} (HCl)

| ATC_prefix = C10

| ATC_suffix = AC02

| PubChem = 62816

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB00375

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = K50N755924

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = C06925

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 1201678

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = none

| chemical_formula = (C₄H₁₀N₃)_m(C₃H₆O)_n

}}

Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL).{{cite journal | vauthors = Handelsman Y | title = Role of bile acid sequestrants in the treatment of type 2 diabetes | journal = Diabetes Care | volume = 34 | issue = Suppl 2 | pages = S244-50 | date = May 2011 | pmid = 21525463 | pmc = 3632187 | doi = 10.2337/dc11-s237 }}{{cite web | work = Drugs.com | url = https://www.drugs.com/monograph/colestipol-hydrochloride.html | title = Colestipol Hydrochloride }} It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.{{cite web | title = colestipol (Colestid) | url = http://www.medicinenet.com/colestipol/article.htm | work = MedicineNet }}

Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.{{Cite book | vauthors = Mutschler E, Schäfer-Korting M |title=Arzneimittelwirkungen |language=German |location=Stuttgart |publisher=Wissenschaftliche Verlagsgesellschaft |year=2001 |edition=8th |page=523 |isbn=3-8047-1763-2 }}