Collecting duct carcinoma
{{Short description|Type of kidney cancer}}
{{Infobox medical condition (new)
| name = Collecting duct carcinoma
| image = Collecting duct carcinoma - 2 WBAL.tif
| caption = Collecting duct carcinoma. H&E stain.
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| field = oncology/nephrology
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File:Bellini duct carcinoma 80jm - CT axial und coronar - 001.jpg
Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.{{cite journal| vauthors = Fakhrai N, Haitel A, Balassy C, Zielinski CC, Schmidinger M| title = Major response and clinical benefit following third-line treatment for Bellini duct carcinoma| journal = Wien. Klin. Wochenschr.| volume = 117| issue = 1–2| pages = 63–5| date = January 2005| pmid = 15986594| doi = 10.1007/s00508-004-0289-4}} It is also recently described; a 2002 review found just 40 case reports worldwide.{{cite journal| vauthors = Singh I, Nabi G| title = Bellini duct carcinoma: review of diagnosis and management| journal = Int Urol Nephrol| volume = 34| issue = 1| pages = 91–5| year = 2002| pmid = 12549647| doi = 10.1023/A:1021315130481| url = http://www.kluweronline.com/art.pdf?issn=0301-1623&volume=34&page=91}} Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.{{cite journal| vauthors = Méjean A, Rouprêt M, Larousserie F, Hopirtean V, Thiounn N, Dufour B| title = Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma?| journal = J. Urol.| volume = 169| issue = 4| pages = 1287–90| date = April 2003| pmid = 12629344| doi = 10.1097/01.ju.0000050221.51509.f5}} However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly.
Signs and symptoms
Signs and symptoms are as for kidney cancer.{{cn|date=April 2021}}
Histology
Histologic examination of collecting duct carcinoma demonstrates an infiltrative lesion with tubulopapillary, irregular channels lined by high grade hobnail cells with marked desmoplastic response and brisk neutrophilic infiltrate.{{cn|date=April 2021}}
Treatment
{{Empty section|date=February 2018}}
History
CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.{{cite journal |author=O Natsume |author2=S Ozono |author3=T Futami |author4=M Ohta |name-list-style=amp |year=1997 |title=Bellini duct carcinoma: a case report |journal=Japanese Journal of Clinical Oncology |volume=27 |issue=2 |pages=107–110 |doi=10.1093/jjco/27.2.107 |pmid=9152800|doi-access= }}
References
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External links
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| ICD10 = C64
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| MeshID = D002292
| Orphanet = 247203
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