Comparative physiology

{{Short description|Study of the diversity of functional characteristics of organisms.}}

Comparative physiology is a subdiscipline of physiology that studies and exploits the diversity of functional characteristics of various kinds of organisms. It is closely related to evolutionary physiology and environmental physiology. Many universities offer undergraduate courses that cover comparative aspects of animal physiology. According to Clifford Ladd Prosser, "Comparative Physiology

is not so much a defined discipline as a viewpoint, a philosophy."

History

Originally, as narrated in a recent history of the field,{{Cite book |last=Anctil |first=Michel |title=Animal as machine - The quest to understand how animals work and adapt. |publisher=McGill-Queen's University Press |year=2022 |isbn=978-0-2280-1053-1 |location=Montreal & Kingston |language=English}} physiology focused primarily on human beings, in large part from a desire to improve medical practices. When physiologists first began comparing different species it was sometimes out of simple curiosity to understand how organisms work but also stemmed from a desire to discover basic physiological principles. This use of specific organisms convenient to study specific questions is known as the Krogh Principle.{{cn|date=June 2022}}

Methodology

C. Ladd Prosser,{{cite journal|last=Greenberg|first=M. J. |author2=P. W. Hochachka |author3=C. P. Mangum |year=1975|title=Biographical data: Clifford Ladd Prosser|journal=Journal of Experimental Zoology|volume=194|issue=1|pages=5–12|doi=10.1002/jez.1401940102|pmid=1104756|bibcode=1975JEZ...194....5G }} a founder of modern comparative physiology, outlined a broad agenda for comparative physiology in his 1950 edited volume (see summary and discussion in Garland and Carter):

1. To describe how different kinds of animals meet their needs.

:This amounts to cataloging functional aspects of biological diversity, and has recently been criticized as "stamp collecting" with the suggestion that the field should move beyond that initial, exploratory phase.{{cite journal|last=Mangum|first=C. P.|author2=P. W. Hochachka|year=1998|title=New directions in comparative physiology and biochemistry: mechanisms, adaptations, and evolution|journal=Physiological Zoology|volume=71|issue=5|pages=471–484|doi=10.1086/515953|pmid=9754524|s2cid=25169635}}

2. The use of physiological information to reconstruct phylogenetic relationships of organisms.

:In principle physiological information could be used just as morphological information or DNA sequence is used to measure evolutionary divergence of organisms. In practice, this has rarely been done, for at least four reasons:

:* physiology doesn't leave many fossil cues,

:* it can't be measured on museum specimens,

:* it is difficult to quantify as compared with morphology or DNA sequences, and

:* physiology is more likely to be adaptive than DNA, and so subject to parallel and convergent evolution, which confuses phylogenetic reconstruction.

3. To elucidate how physiology mediates interactions between organisms and their environments.

:This is essentially physiological ecology or ecological physiology.

4. To identify "model systems" for studying particular physiological functions.

:Examples of this include using squid giant axons to understand general principles of nerve transmission, using rattlesnake tail shaker muscles for measurement of in vivo changes in metabolites (because the whole animal can be put in an NMR machine),{{cite journal|last=Conley|first=K. E.|author2=S. L. Lindstedt|year=1996|title=Rattlesnake tail-shaking: minimal cost per twitch in striated muscle|journal=Nature|volume=383|pmid=8779716|issue=6595|pages=71–73|doi=10.1038/383071a0|s2cid=4283944}} and the use of ectothermic poikilotherms to study effects of temperature on physiology.

5. To use the "kind of animal" as an experimental variable.

: "While other branches of physiology use such variables as light, temperature, oxygen tension, and hormone balance, comparative physiology uses, in addition, species or animal type as a variable for each function."Prosser (1950, p. 1)

: 25 years later, Prosser put things this way: "I like to think of it as that method in physiology which uses kind of organism as one experimental variable."{{cite journal|last=Prosser|first=C. L.|year=1975|title=Prospects for comparative physiology and biochemistry|journal=Journal of Experimental Zoology|volume=194|pmid=1194870|issue=1|pages=345–348|doi=10.1002/jez.1401940122|bibcode=1975JEZ...194..345P }}

Comparative physiologists often study organisms that live in "extreme" environments (e.g., deserts) because they expect to find especially clear examples of evolutionary adaptation.{{cite journal|last=Garland|first=T. Jr.|author2=P. A. Carter|year=1994|title=Evolutionary physiology|url=http://www.biology.ucr.edu/people/faculty/Garland/GarlCa94.pdf|journal=Annual Review of Physiology|volume=56|pages=579–621|doi=10.1146/annurev.ph.56.030194.003051|pmid=8010752|access-date=2007-02-11|archive-date=2021-04-12|archive-url=https://web.archive.org/web/20210412150229/https://biology.ucr.edu/people/faculty/Garland/GarlCa94.pdf|url-status=dead}} One example is the study of water balance in desert-inhabiting mammals, which have been found to exhibit kidney specializations.{{cite journal|last=Al-kahtani|first=M.A.|author2=C. Zuleta|author3=E. Caviedes-Vidal|author4-link=Theodore Garland Jr|author4=T. Garland Jr.|year=2004|title=Kidney mass and relative medullary thickness of rodents in relation to habitat, body size, and phylogeny|url=http://www.biology.ucr.edu/people/faculty/Garland/Al-kahtaniEA2004.pdf|journal=Physiological and Biochemical Zoology|volume=77|issue=3|pages=346–365|doi=10.1086/420941|pmid=15286910|citeseerx=10.1.1.407.8690|s2cid=12420368|access-date=2009-01-17|archive-date=2010-06-17|archive-url=https://web.archive.org/web/20100617221052/http://www.biology.ucr.edu/people/faculty/Garland/Al-kahtaniEA2004.pdf|url-status=dead}}

Similarly, comparative physiologists have been attracted to "unusual" organisms, such as very large or small ones. As an example, of the latter, hummingbirds have been studied. As another example, giraffe have been studied because of their long necks and the expectation that this would lead to specializations related to the regulation of blood pressure. More generally, ectothermic vertebrates have been studied to determine how blood acid-base balance and pH change as body temperature changes.

Funding

In the United States, research in comparative physiology is funded by both the National Institutes of Health and the National Science Foundation.{{cn|date=May 2024}}

Societies

A number of scientific societies feature sections on comparative physiology, including:

[http://www.the-aps.org/ American Physiological Society]
[https://archive.today/20050615133231/http://www.zoo.latrobe.edu.au/anzscpb/ Australian & New Zealand Society for Comparative Physiology & Biochemistry]
[http://www.csz-scz.ca/ Canadian Society of Zoologists]
[https://web.archive.org/web/20120818084515/http://wwwsoc.nii.ac.jp/jscpb/index-e.html Japanese Society for Comparative Physiology and Biochemistry]
[http://sicb.org/ Society for Integrative and Comparative Biology]
Society for Experimental Biology

Biographies

Knut Schmidt-Nielsen (1915–2007) was a major figure in vertebrate comparative physiology, serving on the faculty at Duke University for many years and training a large number of students [https://web.archive.org/web/20070210060243/http://www.dukenews.duke.edu/2007/01/schmidt-nielsen.html (obituary)]. He also authored several books, including an influential text, all known for their accessible writing style.{{cn|date=May 2024}}

Grover C. Stephens (1925–2003) was a well-known invertebrate comparative physiologist, serving on the faculty of the University of Minnesota until becoming the founding chairman of the Department of Organismic Biology at the University of California at Irvine in 1964. He was the mentor for numerous graduate students, many of whom have gone on to further build the field [https://web.archive.org/web/20120221235117/http://www.universityofcalifornia.edu/senate/inmemoriam/GroverC.Stephens.htm (obituary)]. He authored several books and in addition to being an accomplished biologist was also an accomplished pianist and philosopher.

Some journals that publish articles in comparative animal physiology

[https://journals.physiology.org/ajpregu/about American Journal of Physiology - Regulatory, Integrative and Comparative Physiology]
[https://www.annualreviews.org/content/journals/physiol?page=about-journal Annual Review of Physiology]
[https://www.sciencedirect.com/journal/comparative-biochemistry-and-physiology-part-a-physiology Comparative Biochemistry and Physiology]
[https://www.journals.uchicago.edu/journals/ecp/about Ecological and Evolutionary Physiology] (formerly Physiological and Biochemical Zoology)
[https://academic.oup.com/icb/pages/About Integrative and Comparative Biology]
[https://link.springer.com/journal/359 Journal of Comparative Physiology]
[https://journals.biologists.com/jeb/pages/about Journal of Experimental Biology]