Connective tissue nevus

Connective tissue nevi are thickened regions of skin that look as a series of skin-colored papules and plaques. The spots will become discolored in a yellowish manner as the skin covering them is stretched. Occasionally, they could seem red and have enhanced vascularity.{{cite book | last=Weston | first=William L. | last2=Lane | first2=Alfred T. | last3=Morelli | first3=Joseph G. | title=Color Textbook of Pediatric Dermatology | chapter=Skin Diseases in Newborns | publisher=Elsevier | year=2007 | doi=10.1016/b978-0-323-04909-2.50024-2 | page=381–411}}

The majority of reports are of random lesions, but there are some familial cases, indicating autosomal dominant transmission.{{cite journal | last=Saussine | first=Anne | last2=Marrou | first2=Karine | last3=Delanoé | first3=Phillippe | last4=Bodak | first4=Nathalie | last5=Hamel | first5=Dominique | last6=Picard | first6=Arnaud | last7=Sassolas | first7=Bruno | last8=de Prost | first8=Yves | last9=Lemerrer | first9=Martine | last10=Fraitag | first10=Sylvie | last11=Bodemer | first11=Christine | title=Connective tissue nevi: An entity revisited | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=67 | issue=2 | year=2012 | issn=0190-9622 | doi=10.1016/j.jaad.2011.08.008 | pages=233–239}}{{cite journal | last=McCuaig | first=Catherine C. | last2=Vera | first2=Caridad | last3=Kokta | first3=Victor | last4=Marcoux | first4=Danielle | last5=Hatami | first5=Afshin | last6=Thuraisingam | first6=Thusanth | last7=Marton | first7=Dominique | last8=Fortier-Riberdy | first8=Geneviève | last9=Powell | first9=Julie | title=Connective tissue nevi in children: Institutional experience and review | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=67 | issue=5 | year=2012 | issn=0190-9622 | doi=10.1016/j.jaad.2012.01.036 | pages=890–897}} Furthermore, connective tissue nevus can present as solitary lesions or be a component of systemic illnesses like tuberous sclerosis, which features shagreen's patches, another form of collagenoma, as an associated feature, or Buschke–Ollendorff syndrome, which is linked to collagenomas and elastomas.{{cite journal | last=Pope | first=V. | last2=Dupuis | first2=L. | last3=Kannu | first3=P. | last4=Mendoza-Londono | first4=R. | last5=Sajic | first5=D. | last6=So | first6=J. | last7=Yoon | first7=G. | last8=Lara-Corrales | first8=I. | title=Buschke–Ollendorff syndrome: a novel case series and systematic review | journal=British Journal of Dermatology | publisher=Oxford University Press (OUP) | volume=174 | issue=4 | date=2016-03-08 | issn=0007-0963 | doi=10.1111/bjd.14366 | pages=723–729}}{{cite journal | last=Arora | first=Harleen | last2=Falto-Aizpurua | first2=Leyre | last3=Cortés-Fernandez | first3=Andrea | last4=Choudhary | first4=Sonal | last5=Romanelli | first5=Paolo | title=Connective Tissue Nevi: A Review of the Literature | journal=The American Journal of Dermatopathology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=39 | issue=5 | year=2017 | issn=0193-1091 | doi=10.1097/dad.0000000000000638 | pages=325–341}}

In addition to hematoxylin-eosin staining to evaluate histological changes, lesion characteristics, genetic history, and special histochemical staining to highlight the composition of connective tissue nevus for differentiation, these tests are necessary for the diagnosis of connective tissue nevus.{{cite journal | last=Yang | first=Qingqing | last2=Liu | first2=Shengxiu | title=Connective tissue nevus—Isolated collagenoma | journal=Skin Research and Technology | publisher=Wiley | volume=28 | issue=6 | date=2022-10-25 | issn=0909-752X | doi=10.1111/srt.13210 | pages=880–881| pmc=9907574 }}

• Skin lesion
• List of cutaneous conditions

{{reflist}}

• {{cite journal | last=Tirelli | first=F. | last2=Giraudo | first2=C. | last3=Soliani | first3=M. | last4=Calabrese | first4=F. | last5=Martini | first5=G. | last6=Gisondi | first6=P. | last7=Meneghel | first7=A. | last8=Zulian | first8=Francesco | title=Connective tissue nevus misdiagnosed as juvenile localized scleroderma | journal=Pediatric Rheumatology | publisher=Springer Science and Business Media LLC | volume=21 | issue=1 | date=2023-10-17 | issn=1546-0096 | doi=10.1186/s12969-023-00913-9 | doi-access=free | ref=none| pmc=10583392 }}
• {{cite journal | last=Pierard | first=Gerald E. | last2=Lapiere | first2=Charles M. | title=Nevi of connective tissue A reappraisal of their classification | journal=The American Journal of Dermatopathology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=7 | issue=4 | year=1985 | issn=0193-1091 | doi=10.1097/00000372-198508000-00003 | pages=325–334 | ref=none}}

• [https://dermnetnz.org/topics/connective-tissue-naevi DermNet]
• [https://www.visualdx.com/visualdx/diagnosis/connective+tissue+nevi?diagnosisId=53489&moduleId=102 VisualDx]

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Category:Dermal and subcutaneous growths

{{Skin tumors, nevi and melanomas}}