Contactin 1

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

CNTN1 has been shown to interact with PTPRB.{{cite journal | vauthors = Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M | title = Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta | journal = The Journal of Cell Biology | volume = 136 | issue = 4 | pages = 907–18 | date = Feb 1997 | pmid = 9049255 | pmc = 2132488 | doi = 10.1083/jcb.136.4.907 }}{{cite journal | vauthors = Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J | title = The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin | journal = Cell | volume = 82 | issue = 2 | pages = 251–60 | date = Jul 1995 | pmid = 7628014 | doi = 10.1016/0092-8674(95)90312-7 | s2cid = 18084292 | doi-access = free }}

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• {{UCSC gene info|CNTN1}}
• {{UCSC gene info|F3}}

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• {{cite journal | vauthors = Walsh FS, Doherty P | title = Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system | journal = Cell Biology International Reports | volume = 15 | issue = 11 | pages = 1151–66 | date = Nov 1991 | pmid = 1838307 | doi = 10.1016/0309-1651(91)90061-M }}
• {{cite journal | vauthors = Peles E, Schlessinger J, Grumet M | title = Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling | journal = Trends in Biochemical Sciences | volume = 23 | issue = 4 | pages = 121–4 | date = Apr 1998 | pmid = 9584610 | doi = 10.1016/S0968-0004(98)01195-5 | doi-access = free }}
• {{cite journal | vauthors = Olive S, Dubois C, Schachner M, Rougon G | title = The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum | journal = Journal of Neurochemistry | volume = 65 | issue = 5 | pages = 2307–17 | date = Nov 1995 | pmid = 7595520 | doi = 10.1046/j.1471-4159.1995.65052307.x | s2cid = 39142478 }}
• {{cite journal | vauthors = Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J | title = The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin | journal = Cell | volume = 82 | issue = 2 | pages = 251–60 | date = Jul 1995 | pmid = 7628014 | doi = 10.1016/0092-8674(95)90312-7 | s2cid = 18084292 | doi-access = free }}
• {{cite journal | vauthors = Berglund EO, Ranscht B | title = Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12 | journal = Genomics | volume = 21 | issue = 3 | pages = 571–82 | date = Jun 1994 | pmid = 7959734 | doi = 10.1006/geno.1994.1316 }}
• {{cite journal | vauthors = Reid RA, Bronson DD, Young KM, Hemperly JJ | title = Identification and characterization of the human cell adhesion molecule contactin | journal = Brain Research. Molecular Brain Research | volume = 21 | issue = 1–2 | pages = 1–8 | date = Jan 1994 | pmid = 8164510 | doi = 10.1016/0169-328X(94)90372-7 }}
• {{cite journal | vauthors = Yoshihara Y, Kawasaki M, Tamada A, Nagata S, Kagamiyama H, Mori K | title = Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily | journal = Journal of Neurobiology | volume = 28 | issue = 1 | pages = 51–69 | date = Sep 1995 | pmid = 8586965 | doi = 10.1002/neu.480280106 }}
• {{cite journal | vauthors = Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M | title = Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta | journal = The Journal of Cell Biology | volume = 136 | issue = 4 | pages = 907–18 | date = Feb 1997 | pmid = 9049255 | pmc = 2132488 | doi = 10.1083/jcb.136.4.907 }}
• {{cite journal | vauthors = Xiao ZC, Taylor J, Montag D, Rougon G, Schachner M | title = Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11 | journal = The European Journal of Neuroscience | volume = 8 | issue = 4 | pages = 766–82 | date = Apr 1996 | pmid = 9081628 | doi = 10.1111/j.1460-9568.1996.tb01262.x | s2cid = 30389358 }}
• {{cite journal | vauthors = Xiao ZC, Hillenbrand R, Schachner M, Thermes S, Rougon G, Gomez S | title = Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R | journal = Journal of Neuroscience Research | volume = 49 | issue = 6 | pages = 698–709 | date = Sep 1997 | pmid = 9335257 | doi = 10.1002/(SICI)1097-4547(19970915)49:6<698::AID-JNR4>3.0.CO;2-2 | s2cid = 10209383 }}
• {{cite journal | vauthors = Pierre K, Rougon G, Allard M, Bonhomme R, Gennarini G, Poulain DA, Theodosis DT | title = Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons | journal = The Journal of Neuroscience | volume = 18 | issue = 14 | pages = 5333–43 | date = Jul 1998 | pmid = 9651216 | doi = 10.1523/JNEUROSCI.18-14-05333.1998| pmc = 6793479 }}
• {{cite journal | vauthors = Revest JM, Faivre-Sarrailh C, Maeda N, Noda M, Schachner M, Rougon G | title = The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells | journal = The European Journal of Neuroscience | volume = 11 | issue = 4 | pages = 1134–47 | date = Apr 1999 | pmid = 10103110 | doi = 10.1046/j.1460-9568.1999.00521.x | s2cid = 23803785 }}
• {{cite journal | vauthors = Berglund EO, Murai KK, Fredette B, Sekerková G, Marturano B, Weber L, Mugnaini E, Ranscht B | title = Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression | journal = Neuron | volume = 24 | issue = 3 | pages = 739–50 | date = Nov 1999 | pmid = 10595523 | doi = 10.1016/S0896-6273(00)81126-5 | s2cid = 16663068 | doi-access = free }}
• {{cite journal | vauthors = Pierre K, Dupouy B, Allard M, Poulain DA, Theodosis DT | title = Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent | journal = The European Journal of Neuroscience | volume = 14 | issue = 4 | pages = 645–56 | date = Aug 2001 | pmid = 11556889 | doi = 10.1046/j.0953-816x.2001.01682.x | s2cid = 43151749 }}
• {{cite journal | vauthors = Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC | title = Contactin associates with Na+ channels and increases their functional expression | journal = The Journal of Neuroscience | volume = 21 | issue = 19 | pages = 7517–25 | date = Oct 2001 | pmid = 11567041 | doi = 10.1523/JNEUROSCI.21-19-07517.2001| pmc = 6762905 | doi-access = free }}
• {{cite journal | vauthors = Pavlou O, Theodorakis K, Falk J, Kutsche M, Schachner M, Faivre-Sarrailh C, Karagogeos D | title = Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members | journal = Molecular and Cellular Neurosciences | volume = 20 | issue = 3 | pages = 367–81 | date = Jul 2002 | pmid = 12139915 | doi = 10.1006/mcne.2002.1105 | s2cid = 714233 }}
• {{cite journal | vauthors = Garwood J, Heck N, Reichardt F, Faissner A | title = Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth | journal = The Journal of Biological Chemistry | volume = 278 | issue = 26 | pages = 24164–73 | date = Jun 2003 | pmid = 12700241 | doi = 10.1074/jbc.M211721200 | doi-access = free }}

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