CopA-like RNA

{{Short description|Family of non-coding RNAs found on the R1 pyramid}}

{{Infobox rfam

| Name = CopA-like RNA

| image = RF00042.jpg

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| caption = Predicted secondary structure and sequence conservation of CopA

| Symbol = CopA

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| Rfam = RF00042

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| RNA_type = Gene; antisense

| Tax_domain = Bacteria

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| SO = {{SO|0000644}}

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CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.{{cite journal | last = Nordgren | first = S |author2=Slagter-Jager JG|author3=Wagner GH | year = 2001 | title = Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance | journal = J Mol Biol | volume = 310 | pages = 1125–1134 | pmid = 11502000 | doi = 10.1006/jmbi.2001.4802 | issue = 5}}{{cite journal |doi=10.1093/nar/14.6.2523 |vauthors=Gerhart E, Wagner H, Nordström K |title=Structural analysis of an RNA molecule involved in replication control of plasmid R1. |journal=Nucleic Acids Res |volume=14 |issue=6 |pages=2523–2538 |year=1986 |pmid=2421250 |pmc=339680}}{{cite journal |vauthors=Jelloul N, Bouzouita H, Belkahia A |title=[Significance of impedance tests in childhood deafness]. |journal=Tunis Med |volume=57 |issue=4–5 |pages=236–240 |year= 1979|pmid=555093}}