Cornelia Catharina de Lange
{{short description|Dutch pediatrician (1871–1950)}}
{{Infobox person
| name = Cornelia Catharina de Lange
| image = Delange.jpg
| caption =
| othername =
| birth_name =
| birth_date = 24 June 1871
| birth_place = Alkmaar, North Holland
| death_date = 28 January 1950
| death_place = Amsterdam, Holland
| burial_place =
| nationality = Dutch
| alma_mater = University of Amsterdam
| occupation = Pediatrician and neuropathologist
| years_active =
| known_for = Cornelia de Lange syndrome
| spouse =
| award =
| mother =
| father =
| awards = Order of Orange-Nassau
}}
Cornelia Catharina de Lange (24 June 1871 – 28 January 1950) was a Dutch pediatrician and neuropathologist who along with Winfried Brachmann first described the genetic disorder named after her, the Cornelia de Lange syndrome.
Life
Born in Alkmaar to Catharina Jacoba Luchtmans, her mother, and Adrianus Petrus de Lange, a prominent lawyer in the city, de Lange was pushed to pursue an education in chemistry by her father.{{Cite book |last1=Beighton |first1=Peter |url=https://books.google.com/books?id=-TGgBQAAQBAJ |title=The Man Behind the Syndrome |last2=Beighton |first2=Greta |date=2012-12-06 |publisher=Springer Science & Business Media |isbn=978-1-4471-1415-4 |language=en}}{{Cite web |last=Bosch |first=Mineke |date=2019-09-17 |title=Digitaal Vrouwenlexicon van Nederland (Digital Women's Lexicon of the Netherlands) |url=http://resources.huygens.knaw.nl/vrouwenlexicon/lemmata/data/Lange |access-date=2022-03-17 |website= |language=Dutch}} She enrolled in the University of Zurich to study chemistry but changed her focus to medicine in 1892. She graduated from the University of Amsterdam in 1897, becoming the fifth woman physician to qualify in the Netherlands.{{cite web | url =http://www.cdlsusa.org/about-cdls-foundation/our-history.htm|title=History of the CdLS Foundation|publisher=CdLS Foundation| access-date =18 June 2015}}{{Cite web |last=Bosch |first=Mineke |date=2013-11-12 |title=Lange, Cornelia Catharina de (1871-1950) |url=http://resources.huygens.knaw.nl/bwn1880-2000/lemmata/bwn2/langecc |access-date=2022-03-17 |website=Biographical Dictionary of the Netherlands |language=Dutch}} However, because pediatrics did not exist as a specialty in the Netherlands, De Lange moved to Switzerland, where she worked in the children's hospital in Zürich under Oskar Wyss. She then returned to Amsterdam and practiced at Emma Kinderziekenhuis (Emma Children's Hospital).
De Lange worked in all aspects of pediatrics. During her 50 years of practice she collected multiple observations of pediatric disorders.{{Cite journal | last1 = De Knecht-van Eekelen | first1 = Annemarie | last2 = Hennekam | first2 = Raoul C. M. | year = 1994 | title = Historical study: Cornelia C. de Lange (1871–1950)—a pioneer in clinical genetics | journal = American Journal of Medical Genetics | volume = 52 | issue = 3 | pages = 257–266 | doi = 10.1002/ajmg.1320520302 | pmid=7810555}} De Lange also became interested in congenital disorders and their pediatric relevance as theories on human genetics developed during the 1920s and 1930s. In 1933, De Lange described what she called "typus degenerativus Amstelodamensis" (Amsterdam degeneration type) in two children, which became known as Cornelia de Lange syndrome.
She was knighted in 1947 by the Dutch government as a member of the Order of Orange-Nassau.{{Cite web |last=Mueller |first=Jennifer |date=December 2016 |title=Cornelia de Lange Syndrome |url=https://genetics.pediatrics.med.ufl.edu/wordpress/files/2019/03/RCPU-Newsletter-December-2016.pdf |website=RCPU Newsletter |publisher=R.C. Phillips Research and Education Unit}} She died in Amsterdam at the age of 78.
References
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Category:University of Amsterdam alumni
Category:Academic staff of the University of Amsterdam
Category:19th-century Dutch women
Category:19th-century Dutch women physicians
Category:20th-century Dutch women physicians
Category:20th-century Dutch physicians