Coronavirus 3′ UTR pseudoknot

{{Infobox rfam

| Name = Coronavirus 3′ UTR pseudoknot

| image = RF00165-rscape.svg

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| caption = Predicted secondary structure and sequence conservation of Corona_pk3

| Symbol = Corona_pk3

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| Rfam = RF00165

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| RNA_type = Cis-reg

| Tax_domain = Viruses

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| SO = {{SO|0000205}}

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The Coronavirus 3′ UTR pseudoknot is an RNA structure found in the coronavirus genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genomes. The 3′ UTR region of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot structure which is necessary for viral genome replication.{{cite journal | vauthors = Williams GD, Chang RY, Brian DA | title = A phylogenetically conserved hairpin-type 3′ untranslated region pseudoknot functions in coronavirus RNA replication | journal = Journal of Virology | volume = 73 | issue = 10 | pages = 8349–8355 | date = October 1999 | doi = 10.1128/JVI.73.10.8349-8355.1999 | pmid = 10482585 | pmc = 112852 }} The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.

Other RNA families identified in the coronavirus include the coronavirus frameshifting stimulation element, the coronavirus 3′ stem-loop II-like motif (s2m) and the coronavirus packaging signal.