Craig plot
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The Craig plot, named after Paul N. Craig, is a plot of two substituent parameters (e.g. Hansch-Fujita π constant and sigma constant) used in rational drug design.{{Cite web |url=http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |title=IUPAC glossary |access-date=2006-12-14 |archive-url=https://web.archive.org/web/20061209044630/http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |archive-date=2006-12-09 |url-status=dead }}
Two most used forms of a Craig plot are
- plotting the sigma constants of the Hammett equation versus hydrophobicity
- plotting the steric terms of the Taft equation against hydrophobicity
See also
References
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Further reading
- {{cite journal|doi=10.1021/jm00290a004 | volume=14 | title=Interdependence between physical parameters and selection of substituent groups for correlation studies | journal=Journal of Medicinal Chemistry | pages=680–684 | last1 = Craig | first1 = Paul N.| year=1971 | issue=8 | pmid=5114063 }}
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