Creative Biolabs
{{short description|American biotechnology company}}
{{Infobox company
| name = Creative Biolabs, Inc.
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| type = Corporation
| industry = Biotechnology
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| foundation = 2005
| location_country = US
| location = 45-1 Ramsey Road, Shirley, New York 11967
| products = Premade antibody, peptide libraries
| services = Antibody discovery services, antibody engineering services, bio-manufacturing
| website = {{url|www.creative-biolabs.com/aboutus.html}}
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Creative Biolabs, Inc. is a life-science company which produces and supplies biotech products and services for early drug discovery and development, including various phage display libraries{{Cite web|url=http://www.pr.com/press-release/512637|title=Creative Biolabs Works with UEC for Commercial Phage Display Technology|website=PR.com|access-date=2017-05-18}} such as pre-made libraries,{{Cite journal|title= Practical Tips for Construction of Custom Peptide Libraries and Affinity Selection by Using Commercially Available Phage Display Cloning Systems| pmc=3444042 | pmid=22991651 | doi=10.1155/2012/295719| volume=2012| journal=J Nucleic Acids| page=295719 | last1 = Fukunaga | first1 = K | last2 = Taki | first2 = M| year=2012 | doi-access=free }} phage display services,{{Cite web|url=http://www.biospace.com/News/creative-biolabs-announced-phage-display/442795|title=Creative Biolabs Announced Phage Display Technology For Anti-membrane Protein Antibody Production|website=BioSpace|access-date=2017-05-18}}{{Cite web|url=http://markets.ask.com/ask/news/read/33123649|title=Creative Biolabs Announces A Successful Completion Of Virbac's Unique Monoclonal Antibody Discovery Project Through Cooperation With In-Cell-Art|website=ASK |access-date=2017-05-18}} antibody sequencing,{{Cite web|url=http://www.prweb.com/releases/2015/04/prweb12651813.htm|archive-url=https://web.archive.org/web/20150422221337/http://www.prweb.com/releases/2015/04/prweb12651813.htm|url-status=dead|archive-date=April 22, 2015|title=Creative Biolabs Introduces Innovative Antibody Sequencing Service with DASS Technology for Quicker Testing and Guaranteed Results|website=PRWeb |access-date=2017-05-18}} and antibody humanization.{{Cite web|url=http://www.einpresswire.com/article/280130721/creative-biolabs-updates-its-antibody-humanization-service-to-further-accelerate-your-monoclonal-antibody-research|title=Creative Biolabs Updates Its Antibody Humanization Service to Further Accelerate Your Monoclonal Antibody Research|website=EIN Presswire|date=8 August 2015|access-date=2017-05-18}} Customers include pharmaceutical companies, academic institutions, government agencies, clinical research organizations and biotechnology companies.
History
Creative Biolabs Inc. was founded in 2005 by a group of scientists researching on the treatment and prevention of intractable diseases like cancer. The company has distributors in Australia, New Zealand, Japan and other countries in Europe, Asia, and America. Its headquarter is in Shirley, New York.{{Cite web|url= https://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapId=183064699|title= Company Overview of Creative Biolabs Inc.|website= Bloomberg|access-date=2017-05-18}} In June 2017, Creative Biolabs set up its first scholarship program.{{Cite web|url= http://thenode.biologists.com/event/creative-biolabs-scholarship-program|title= Creative Biolabs Scholarship Program|website=The Company of Biologists|access-date=2017-05-18}}
Services
Fab construction{{Cite journal|last1=Wanczyk|first1=Heather|last2=Barker|first2=Tolga|last3=Rood|first3=Debra|last4=Zapata|first4=Daniel I.|last5=Howell|first5=Amy R.|last6=Richardson|first6=Stewart K.|last7=Zinckgraf|first7=John|last8=Marusov|first8=Gregory P.|last9=Lynes|first9=Michael A.|date=2013-03-19|title=Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Specific Monoclonal Antibody and Recombinant F(ab)|journal=Toxins|volume=5|issue=3|pages=568–589|doi=10.3390/toxins5030568|issn=2072-6651|pmc=3705279|pmid=23518474|doi-access=free}} is a complex technique as Fab fragments contain both variable domains and constant regions. The same heavy and light variable chains used for scFv construction can be used in the construction of Fab.
Construction of pre-made phage display libraries. Pre-made phage display library{{cite patent|title=Glycopeptides and methods of making and using them|pubdate=Oct 13, 2015|inventor-last=Franco|inventor-first=Alessandra|country=US|number=9156906}} is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.
Sequencing services{{Cite journal|last1=Hammerberg|first1=Bruce|last2=Eguiluz-Hernandez|first2=Sitka|date=2017-02-01|title=Therapeutic anti-IgE monoclonal antibody single chain variable fragment (scFv) safety and immunomodulatory effects after one time injection in four dogs|journal=Veterinary Dermatology|language=en|volume=28|issue=1|pages=52–e13|doi=10.1111/vde.12354|pmid=27426720|s2cid=22605797|issn=1365-3164}} such as Database Assisted Shotgun Sequencing (DASS) technology
Analysis of microarray hybridization data{{Cite journal|last1=Gass|first1=Justin T.|last2=Olive|first2=M. Foster|date=2008-04-28|title=Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 antagonists MPEP and MTEP|journal=European Journal of Pharmacology|volume=584|issue=2–3|pages=253–262|doi=10.1016/j.ejphar.2008.02.032|issn=0014-2999|pmc=2386089|pmid=18346726}}
Products
Monoclonal antibodies such as mouse anti-human Duox2 monoclonal antibody S-40{{Cite journal|last1=Wu|first1=Yongzhong|last2=Antony|first2=Smitha|last3=Juhasz|first3=Agnes|last4=Lu|first4=Jiamo|last5=Ge|first5=Yun|last6=Jiang|first6=Guojian|last7=Roy|first7=Krishnendu|last8=Doroshow|first8=James H.|date=2011-04-08|title=Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines|journal=The Journal of Biological Chemistry|volume=286|issue=14|pages=12245–12256|doi=10.1074/jbc.M110.191031|issn=0021-9258|pmc=3069428|pmid=21321110|doi-access=free}}
Immunoglobulin Y (IgY) such as Anti-ADP3 chicken IgY{{Cite journal|last1=Morimoto|first1=Jumpei|last2=Sarkar|first2=Mohosin|last3=Kenrick|first3=Sophia|last4=Kodadek|first4=Thomas|date=2014-08-20|title=Dextran as a Generally Applicable Multivalent Scaffold for Improving Immunoglobulin-Binding Affinities of Peptide and Peptidomimetic Ligands|journal=Bioconjugate Chemistry|volume=25|issue=8|pages=1479–1491|doi=10.1021/bc500226j|issn=1043-1802|pmc=4140544|pmid=25073654}}
Antibody libraries such as HuSdLTM phage display human single domain antibody library{{Cite journal|last1=Ma|first1=Lin|last2=Gu|first2=Kai|last3=Zhang|first3=Cheng-hai|last4=Chen|first4=Xue-tao|last5=Jiang|first5=Yi|last6=Melcher|first6=Karsten|last7=Zhang|first7=Juan|last8=Wang|first8=Min|last9=Xu|first9=H Eric|date=June 2016|title=Generation and characterization of a human nanobody against VEGFR-2|journal=Acta Pharmacologica Sinica|volume=37|issue=6|pages=857–864|doi=10.1038/aps.2016.2|issn=1671-4083|pmc=4954766|pmid=27108602}}
Response to COVID-19
Creative Biolabs offers SARS-CoV-2 S antibodies that come from common hosts like human, mouse, and rabbit, and apply to various lab tests, like ELISA, FC, ICC/IF, etc. Apart from S protein antibodies, Creative Biolabs also provides a comprehensive list of anti-SARS-CoV-2 antibodies to assist with the research and development of drug and vaccine candidates, including but not limited to antibodies targeting genes like N, S1/S2, and ORF7a.{{Cite web|url= https://www.marketwatch.com/press-release/creative-biolabs-supplies-resourceful-antibodies-for-research-use-on-the-covid-19-2020-07-01|title= Creative Biolabs Supplies Resourceful Antibodies for Research Use on the COVID-19|website= MarketWatch|access-date=2020-08-10}}
Creative Biolabs Scholarship Program
Since the first scholarship program in 2017, Creative Biolabs has released scholarship every year. The scholarship award of $1,000 is given to one student of freshman, undergraduate, graduate or Ph.D. level majoring in science-related fields such as Biology, Biochemistry, Chemistry and Molecular Biology.{{Cite web|url= https://www.scholarships.com/creative-biolabs-scholarship-program|title= Creative Biolabs Scholarship Program|website= scholarships|access-date=2020-08-10}}