Croton oil

{{short description|Oil from the seed of Croton tiglium}}

{{about|the plant called "Croton tiglium" in Southeast Asia|the croton oil from East Africa that is used for biofuels |Croton megalocarpus|}}

Croton oil (Crotonis oleum) is an oil prepared from the seeds of Croton tiglium,{{cite EB1911 |wstitle=Croton Oil |volume=7 |page=511}} a tree belonging to the order Euphorbiales and family Euphorbiaceae, and native or cultivated in India and the Malay Archipelago. Small doses taken internally cause diarrhea. Externally, the oil can cause irritation and swelling. Croton oil is used in Phenol-croton oil chemical peels{{cite journal |last1=Wambier |first1=CG |last2=Lee |first2=KC |last3=Soon |first3=SL |last4=Sterling |first4=JB |last5=Rullan |first5=PP |last6=Landau |first6=M |last7=Brody |first7=HJ |last8=International Peeling |first8=Society. |title=Advanced chemical peels: Phenol-croton oil peel. |journal=Journal of the American Academy of Dermatology |date=August 2019 |volume=81 |issue=2 |pages=327–336 |doi=10.1016/j.jaad.2018.11.060 |pmid=30550827|s2cid=54631945 }} for its caustic exfoliating effects it has on the skin.{{Cite journal | pmid = 26397611

| year = 2015

| last1 = Orra

| first1 = S

| title = Periorbital Phenol-Croton Oil Chemical Peel in Conjunction with Blepharoplasty: An Evolving Technique for Periorbital Facial Rejuvenation

| journal = Plastic and Reconstructive Surgery

| volume = 136

| issue = 4 Suppl

| pages = 99–100

| last2 = Waltzman

| first2 = J. T.

| last3 = Mlynek

| first3 = K

| last4 = Duraes

| first4 = E. F.

| last5 = Kundu

| first5 = N

| last6 = Zins

| first6 = J. E.

| doi = 10.1097/01.prs.0000472401.26529.67

| doi-access = free

}} Used in conjunction with phenol solutions, it results in an intense reaction that leads to initial skin sloughing. Since croton oil is very irritating and painful, it is used in laboratory animals to study how pain works, pain-relieving and anti-inflammatory drugs, and immunology.{{Cite book | title = Methods in Pain Research | editor = Lawrence Kruger | publisher = CRC Press | date = 2001}}

Because croton tiglium oil is cocarcinogenic, it has been used in tumor research.{{cite journal| pmc = 2007538| year = 1947| last1 = Berenblum| first1 = I| title = The Role of Croton Oil Applications, Associated with a Single Painting of a Carcinogen, in Tumour Induction of the Mouse's Skin| journal = British Journal of Cancer| volume = 1| issue = 4| pages = 379–382| last2 = Shubik| first2 = P| pmid = 18906315| doi=10.1038/bjc.1947.35}}

Berenblum and Shubik saw croton oil as a “promoting” agent:{{cite journal |last1=Preston |first1=R. D. |last2=Nicolai |first2=E. |last3=Reed |first3=R. |last4=Millard |first4=A. |title=An Electron Microscope Study of Cellulose in the Wall of Valonia Ventricosa |journal=Nature |date=October 1948 |volume=162 |issue=4121 |pages=665–667 |doi=10.1038/162665a0 |pmid=18888170 |bibcode=1948Natur.162..665P |s2cid=4007842 }} a kind of carcinogen that acted through an inflammatory response. Mice painted only with croton oil hadn’t developed tumors.

Croton oil is the source of the chemical compound phorbol.{{cite journal | author = Meyer-Bertenrath, JG | title = 150 Years of croton oil research | journal = Experientia | volume = 25 | issue = 1 | pages = 1–5 | year = 1969 | pmid = 4885798| doi = 10.1007/BF01903855 | s2cid = 26826980 }} Tumor promotion activity was traced to phorbol esters present in croton oil.{{Cite journal|url=http://legacy.library.ucsf.edu/tid/pvx8aa00|title=Phorbol esters from croton oil: Chemical nature and biological activities|author=E. Hecker|journal=Naturwissenschaften|volume=54|issue=11|pages=282–4|date=1967-01-31|bibcode=1967NW.....54..282H|doi=10.1007/BF00620887|pmid=5589922|s2cid=27775957|url-access=subscription}} Pure phorbol 12-myristate 13-acetate, which is found in croton oil, is widely used in laboratory research to induce tumor development.

History of use

During World War II, the United States Navy added a small amount of croton oil to the neutral grain spirits that powered torpedoes. The oil was intended to prevent sailors from drinking the alcohol fuel. Sailors devised crude stills to separate the alcohol from the croton oil, as alcohol evaporates at a lower temperature than croton oil.Ostlund, Mike. [https://books.google.com/books?id=9ABtEMGBmhYC&pg=PA88 Find 'em, chase 'em, sink 'em], Globe Pequot, 2006, p. 88. {{ISBN|1-59228-862-6}}

Norwegian partisans among workers at a factory, ordered by the Quisling government to turn over a catch of sardines to the Nazi German government for shipment to Saint-Nazaire (a U-boat base of operations) arranged with the British for a large shipment of croton oil to covertly poison the sardines, whose fishy taste was expected to conceal the tampering.{{cite book|url=https://books.google.com/books?id=ZDZ1f44NvJcC&pg=PA190|title=Deceptions of World War II|author=William B. Breuer|date=2002|publisher=Wiley & Sons|isbn=9780471207474}}

In "The Bulletin" (9 Dowry Square, Hot Wells, May 29, 1845,) the Reverend Richard Harris Barham wrote a medically inspired poem to relieve the anxiety of a very dear friend a month before his own death on June 17, 1845. The attending doctor advises his patient, among other treatments for a sore throat that is producing barely a sound: "... Please put out your tongue again! / Now the blister! / Ay, the blister! / Let your son, or else his sister, / Warm it well, then clap it here, sir, / All across from ear to ear, sir; / That suffices, / When it rises, / Snip it, sir, and then your throat on / Rub a little oil of Croton: / Never mind a little pain! / Please put out your tongue again! ..." The patient was Barham, who had accidentally swallowed a piece of pear core that got into his windpipe on October 28, 1844. Despite the "professional" advice and the very painful and "highest quality" treatments of the time being given freely to him by Doctors Roberts and Scott, and by the eminent surgeon Mr. Coulson, for "violent vomiting", "inflamed throat", and catching "a cold" in April 1845, Barham died.

"Medicinal" croton oil was supplied in the California Genocide to dying Indian groups.The California Indians, a clever satire on the government's dealings with its Indian wards. From his Crusoe's island ... 1864, p. 284-308, Publication date 1919? John Ross Browne, 1821-1875 https://archive.org/details/californiaindians00browrich/page/8/mode/2up accessed 30 March 2023

References