Cyclin E2

{{protein

|Name=cyclin E2

|caption=

|image=

|width=

|HGNCid=1590

|Symbol=CCNE2

|AltSymbols=

|EntrezGene=9134

|OMIM=603775

|RefSeq=NM_057749

|UniProt=O96020

|PDB=

|ECnumber=

|Chromosome=8

|Arm=q

|Band=22.1

|LocusSupplementaryData=

}}

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).{{cite journal | vauthors = Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S | title = Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 612–22 | date = January 1999 | pmid = 9858585 | pmc = 83919 | doi = 10.1128/mcb.19.1.612 }} It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.

References

{{Cite journal |last1=Zariwala |first1=M. |last2=Liu |first2=J. |last3=Xiong |first3=Y. |date=1998-11-26 |title=Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins |journal=Oncogene |volume=17 |issue=21 |pages=2787–2798 |doi=10.1038/sj.onc.1202505 |issn=0950-9232 |pmid=9840943|s2cid=7340570 |doi-access=free }}

Category:Proteins