Cyclomaltodextrinase

{{infobox enzyme

| Name = Cyclomaltodextrinase

| EC_number = 3.2.1.54

| CAS_number = 37288-41-8

| GO_code = 0047798

| image =

| width =

| caption =

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The enzyme cyclomaltodextrinase ({{EnzExplorer|3.2.1.54}}) catalyzes the chemical reaction

:cyclomaltodextrin + H2O \rightleftharpoons linear maltodextrin

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is cyclomaltodextrin dextrin-hydrolase (decyclizing). Other names in common use include cycloheptaglucanase, cyclohexaglucanase, and cyclodextrinase. The enzyme participates in starch and sucrose metabolism and acarbose degradation.{{Cite journal| vauthors = Jang MU, Jeong CK, Kang HJ, Kim MJ, Lee MJ, Son BS, Kim TJ |date=2016|title=Gene Cluster Analysis and Functional Characterization of Cyclomaltodextrinase from Listeria innocua |journal=Microbiology and Biotechnology Letters|volume=44|issue=3|pages=363–369|doi=10.4014/mbl.1608.08008|issn=1598-642X}}{{cite journal | vauthors = Jang MU, Kang HJ, Jeong CK, Kang Y, Park JE, Kim TJ | title = Functional expression and enzymatic characterization of Lactobacillus plantarum cyclomaltodextrinase catalyzing novel acarbose hydrolysis | journal = Journal of Microbiology | volume = 56 | issue = 2 | pages = 113–118 | date = February 2018 | pmid = 29392561 | doi = 10.1007/s12275-018-7551-3 }} The cyclomaltodextrinase is capable of degradation of acarbose to glucose and acarviosine-glucose.{{Cite journal| vauthors = Park KH |date=2006|title=Function and Tertiary- and Quaternary-structure of Cyclodextrin-hydrolyzing Enzymes (CDase), a Group of Multisubstrate Specific Enzymes Belonging to the α-Amylase Family |journal=Journal of Applied Glycoscience|volume=53|issue=1|pages=35–44|doi=10.5458/jag.53.35|doi-access=free}}

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1EA9}} and {{PDB link|1H3G}}.

References

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Further reading

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  • {{cite journal | vauthors = DePinto JA, Campbell LL | title = Purification and properties of the cyclodextrinase of Bacillus macerans | journal = Biochemistry | volume = 7 | issue = 1 | pages = 121–125 | date = January 1968 | pmid = 4922856 | doi = 10.1021/bi00841a016 }}

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{{Sugar hydrolases}}

{{Enzymes}}

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Category:EC 3.2.1

Category:Enzymes of known structure

{{3.2-enzyme-stub}}