Cysteine—tRNA ligase

{{infobox enzyme

| Name = Cysteine—tRNA ligase

| EC_number = 6.1.1.16

| CAS_number = 37318-56-2

| GO_code = 0004817

| image =

| width =

| caption =

}}

In enzymology, a cysteine—tRNA ligase ({{EnzExplorer|6.1.1.16}}) is an enzyme that catalyzes the chemical reaction:

:ATP + L-cysteine + tRNACys $\rightleftharpoons$ AMP + diphosphate + L-cysteinyl-tRNACys

The three substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its three products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-tRNA biosynthesis.

Structural studies

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1LI5}}, {{PDB link|1LI7}}, and {{PDB link|1U0B}}.

References

{{cite journal | vauthors = Mccorquodale DJ | title = The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coli | journal = Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects | volume = 91 | pages = 541–8 | date = December 1964 | issue = 4 | issn= 0926-6550 | publisher= Elsevier | pmid = 14262440 | doi = 10.1016/0926-6550(64)90001-5 | url= https://www.sciencedirect.com/science/article/abs/pii/0926655064900015 | url-access= subscription | lang= en }}

Category:EC 6.1.1

Category:Enzymes of known structure