DCHS2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.{{cite web | title = Entrez Gene: dachsous 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54798}}{{cite journal | vauthors = Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y | title = Identification of new human cadherin genes using a combination of protein motif search and gene finding methods | journal = Journal of Molecular Biology | volume = 337 | issue = 2 | pages = 307–317 | date = March 2004 | pmid = 15003449 | doi = 10.1016/j.jmb.2004.01.026 }}
DCHS2 has been implicated in the nose angle (how much a nose is upturned).{{cite journal | vauthors = Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, Jaramillo C, Arias W, Lozano RB, Pérez GM, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Cheeseman M, Rosique J, Bedoya G, Rothhammer F, Headon D, González-José R, Balding D, Ruiz-Linares A | title = A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation | journal = Nature Communications | volume = 7 | pages = 11616 | date = May 2016 | pmid = 27193062 | pmc = 4874031 | doi = 10.1038/ncomms11616 | bibcode = 2016NatCo...711616A }} As well as facial genetics {{cite journal | vauthors = Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A | title = Facial Genetics: A Brief Overview | journal = Frontiers in Genetics | volume = 9 | issue = | pages = 462 | date = 2018 | pmid = 30386375 | pmc = 6198798 | doi = 10.3389/fgene.2018.00462 | doi-access = free }}{{cite web | vauthors = Firger J | title = Your nose--Big or small--is shaped by your DNA| work = Newsweek | date=19 May 2016 |url = https://www.newsweek.com/nose-shape-and-size-genes-dna-evolution-461626}}
References
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Further reading
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- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
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