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DDOST

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.{{cite journal | vauthors = Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T | title = Genome organization of human 48-kDa oligosaccharyltransferase (DDOST) | journal = Genomics | volume = 45 | issue = 3 | pages = 535–40 |date=Jan 1998 | pmid = 9367678 | doi = 10.1006/geno.1997.4966 }}{{cite web | title = Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1650}}

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.

References

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Further reading

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  • {{cite journal | vauthors=Kumar V, Korza G, Heinemann FS, Ozols J |title=Human oligosaccharyltransferase: isolation, characterization, and the complete amino acid sequence of 50-kDa subunit |journal=Arch. Biochem. Biophys. |volume=320 |issue= 2 |pages= 217–23 |year= 1995 |pmid= 7625827 |doi=10.1016/0003-9861(95)90003-9 }}
  • {{cite journal | vauthors=Nagase T, Miyajima N, Tanaka A |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=10.1093/dnares/2.1.37 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Stitt AW, He C, Vlassara H |title=Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 549–56 |year= 1999 |pmid= 10080935 |doi= 10.1006/bbrc.1999.0291 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Lu C, He JC, Cai W |title=Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 32 |pages= 11767–72 |year= 2004 |pmid= 15289604 |doi= 10.1073/pnas.0401588101 | pmc=511050 |bibcode=2004PNAS..10111767L |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Shibatani T, David LL, McCormack AL |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982–92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f |display-authors=etal}}
  • {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}

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