DDR1

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein.{{cite journal | vauthors = Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R | title = Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling | journal = The Journal of Biological Chemistry | volume = 288 | issue = 11 | pages = 7430–7 | date = Mar 2013 | pmid = 23335507 | pmc = 3597784 | doi = 10.1074/jbc.R112.444158 | doi-access = free }} In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

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• {{cite journal | vauthors = Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA | title = Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 973–81 | date = May 2000 | pmid = 10783152 | doi = 10.1096/fasebj.14.7.973| doi-access = free | s2cid = 43317719 }}
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• {{cite journal | vauthors = Mohan RR, Mohan RR, Wilson SE | title = Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea | journal = Experimental Eye Research | volume = 72 | issue = 1 | pages = 87–92 | date = Jan 2001 | pmid = 11133186 | doi = 10.1006/exer.2000.0932 }}

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{{Clusters of differentiation}}

{{Tyrosine kinases}}

{{Enzymes}}

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Category:Clusters of differentiation

Category:Tyrosine kinase receptors

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