DDX24
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Context|date=July 2016}}
{{Infobox_gene}}
ATP-dependent RNA helicase DDX24 is an enzyme that in humans is encoded by the DDX24 gene.{{cite journal | vauthors = Zhao Y, Yu L, Fu Q, Chen W, Jiang J, Gao J, Zhao S | title = Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32 | journal = Genomics | volume = 67 | issue = 3 | pages = 351–5 |date=Sep 2000 | pmid = 10936056 | doi = 10.1006/geno.2000.6255 }}{{cite web | title = Entrez Gene: DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57062}}
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial RNA splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level.
References
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Further reading
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- {{cite journal | vauthors=Jung SY, Malovannaya A, Wei J |title=Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. |journal=Mol. Endocrinol. |volume=19 |issue= 10 |pages= 2451–65 |year= 2005 |pmid= 16051665 |doi= 10.1210/me.2004-0476 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|doi-access=free |hdl=11858/00-001M-0000-0010-8592-0 |hdl-access=free }}
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- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
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