DEFB106A
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.{{cite journal | vauthors = Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, ((McCray PB Jr)) | title = Discovery of five conserved beta -defensin gene clusters using a computational search strategy | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 4 | pages = 2129–33 |date=Feb 2002 | pmid = 11854508 | pmc = 122330 | doi = 10.1073/pnas.042692699 | bibcode = 2002PNAS...99.2129S | doi-access = free }}{{cite web | title = Entrez Gene: DEFB106A defensin, beta 106A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=245909| accessdate = }}
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.
Function
The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.{{cite journal | author = Xin A | title = Soluble fusion expression, characterization and localization of human β-defensin 6... | journal = Mol Med Rep | volume = 9 | issue = 1|date=Jan 2014 | pmid = 24189797 | url = http://www.spandidos-publications.com/mmr/9/1/149 | pages = 149–55 | doi=10.3892/mmr.2013.1768| doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors=Yamaguchi Y, Nagase T, Makita R |title=Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2516–23 |year= 2002 |pmid= 12193721 |doi= 10.4049/jimmunol.169.5.2516|display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Kao CY, Chen Y, Zhao YH, Wu R |title=ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes. |journal=Am. J. Respir. Cell Mol. Biol. |volume=29 |issue= 1 |pages= 71–80 |year= 2003 |pmid= 12600824 |doi= 10.1165/rcmb.2002-0205OC |citeseerx=10.1.1.108.7808 }}
- {{cite journal | vauthors=Semple CA, Rolfe M, Dorin JR |title=Duplication and selection in the evolution of primate beta-defensin genes. |journal=Genome Biol. |volume=4 |issue= 5 |pages= R31 |year= 2003 |pmid= 12734011 |doi=10.1186/gb-2003-4-5-r31 | pmc=156587 |doi-access=free }}
- {{cite journal | vauthors=Hollox EJ, Armour JA, Barber JC |title=Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. |journal=Am. J. Hum. Genet. |volume=73 |issue= 3 |pages= 591–600 |year= 2003 |pmid= 12916016 |doi= 10.1086/378157 | pmc=1180683 }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Taudien S, Galgoczy P, Huse K |title=Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. |journal=BMC Genomics |volume=5 |pages= 92 |year= 2006 |pmid= 15588320 |doi= 10.1186/1471-2164-5-92 | pmc=544879 |issue=1|display-authors=etal |doi-access=free }}
- {{cite journal | vauthors=Boniotto M, Ventura M, Eskdale J |title=Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. |journal=Genet. Test. |volume=8 |issue= 3 |pages= 325–7 |year= 2005 |pmid= 15727258 |doi=10.1089/gte.2004.8.325 |display-authors=etal}}
- {{cite journal | vauthors=Patil AA, Cai Y, Sang Y |title=Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. |journal=Physiol. Genomics |volume=23 |issue= 1 |pages= 5–17 |year= 2006 |pmid= 16033865 |doi= 10.1152/physiolgenomics.00104.2005 |s2cid=22355626 |display-authors=etal}}
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