DENND1B
{{Short description|Human gene}}
{{More citations needed|date=January 2018}}
{{infobox_gene}}
DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1.
Structure
The protein has tripartite DENN domain at N-terminal.
Functions
The protein is a guanine nucleotide exchange factor for RAB35.{{cite journal|journal=Journal of Cell Biology|title=Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors|vauthors=Yoshimura S, etal|url=https://rupress.org/jcb/article/191/2/367/36173/Family-wide-characterization-of-the-DENN-domain|doi=10.1083/jcb.201008051}}
Clinical significance
The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma.{{Cite web |url=http://www.videnskab.dk/composite-3634.htm |title=Nyt genfund kan skåne børn for astma |access-date=2010-01-08 |archive-date=2013-02-13 |archive-url=https://archive.today/20130213025243/http://www.videnskab.dk/composite-3634.htm |url-status=dead }} The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis.{{cite journal | vauthors = Smith NL, Hankinson J, Simpson A, Denning DW, Bowyer P | title = Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT | journal = Clinical Microbiology and Infection | volume = 20 | issue = 11 | pages = O960-8 | date = November 2014 | pmid = 24712925 | doi = 10.1111/1469-0691.12643 | doi-access = free }} Variants of this gene are also associated with obesity in both humans and dogs.{{cite journal|journal=Science|title=Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans|vauthors=Wallis NJ, etal|url=https://www.science.org/doi/10.1126/science.ads2145|doi=10.1126/science.ads2145|url-access=subscription}}