DES

DES or Des may refer to:

Computing

Data Encryption Standard, a block cipher that is no longer secure for today's standards
DirectShow Editing Services, an Application Programming Interface
Discrete event simulation, a kind of scientific modelling

Deccan Education Society, a private education institution based in Pune, India.
Department of Education and Science (UK), the former name of the Department for Education and Skills
{{ill|Diplôme d'études supérieures|fr|Diplôme d'études supérieures en France}}, a former degree used in France and French-speaking countries

Diethylstilbestrol, a synthetic estrogen and the origin of the phrase "DES daughter"
DES gene, which encodes the desmin protein
Diffuse esophageal spasm, a disorder of the esophagus
Dissociative Experiences Scale, a questionnaire to screen for dissociative identity disorder
Drug-eluting stent, a medical device
Dry eye syndrome, also known as keratoconjunctivitis sicca
Dysequilibrium syndrome, a congenital disorder of the nervous system

Dar es Salaam
Dark Energy Survey, an astronomy project
Deep Ecliptic Survey, an astronomy project
Deep eutectic solvent, an ionic solvent
Defence Equipment and Support, British MOD's defence procurement arm
Delivered Ex Ship, an international sales term
Detached eddy simulation, a model in fluid dynamics
Des, a three-part British series about serial killer Dennis Nilsen
Desroches Airport, by IATA code
Arizona Department of Economic Security, a US government organization providing a variety of social support services to Arizona residents
Desmond (name), a male given name in shortened form
Desiree (given name), a female given name in shortened form
Diethyl sulfate, an organic chemical