DFE

• Department for the Economy, Northern Ireland
• Department for Education, UK
• DePatie–Freleng Enterprises, a defunct American animation studio

• Dilated fundus examination of the eye
• Distribution of fitness effects
• Dietary folate equivalent, bioavailability of folate
• 1,1-Difluoroethane

• Design-focused evaluation of educational quality
• Design for the Environment of a product or service
• DFE Ascender, an ultralight aircraft

• Dragon Fli Empire, a Canadian hip hop group
• Dunfermline Town railway station, Scotland, National Rail station code
• The Duke of Edinburgh's Award, commonly referred to as 'DofE'

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