Login
Login

DGKD

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.{{cite journal | vauthors = Sakane F, Imai S, Kai M, Wada I, Kanoh H | title = Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases | journal = J Biol Chem | volume = 271 | issue = 14 | pages = 8394–401 |date=Jun 1996 | pmid = 8626538 | doi =10.1074/jbc.271.14.8394 | doi-access = free }}{{cite journal | vauthors = Murakami T, Sakane F, Imai S, Houkin K, Kanoh H | title = Identification and characterization of two splice variants of human diacylglycerol kinase eta | journal = J Biol Chem | volume = 278 | issue = 36 | pages = 34364–72 |date=Sep 2003 | pmid = 12810723 | doi = 10.1074/jbc.M301542200 | doi-access = free }}{{cite web | title = Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8527}}

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Nagase T, Seki N, Tanaka A |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=10.1093/dnares/2.4.167 |display-authors=etal|doi-access= |citeseerx=10.1.1.333.6945 }}
  • {{cite journal | vauthors=Bregoli L, Baldassare JJ, Raben DM |title=Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23288–95 |year= 2001 |pmid= 11309392 |doi= 10.1074/jbc.M101501200 |doi-access= free }}
  • {{cite journal | vauthors=Nagaya H, Wada I, Jia YJ, Kanoh H |title=Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. |journal=Mol. Biol. Cell |volume=13 |issue= 1 |pages= 302–16 |year= 2002 |pmid= 11809841 |doi= 10.1091/mbc.01-05-0255 | pmc=65090 }}
  • {{cite journal | vauthors=Imai S, Sakane F, Kanoh H |title=Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35323–32 |year= 2002 |pmid= 12084710 |doi= 10.1074/jbc.M202035200 |doi-access= free }}
  • {{cite journal | vauthors=Sakane F, Imai S, Yamada K |title=Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43519–26 |year= 2003 |pmid= 12200442 |doi= 10.1074/jbc.M206895200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Imai S, Kai M, Yamada K |title=The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. |journal=Biochem. J. |volume=382 |issue= Pt 3 |pages= 957–66 |year= 2005 |pmid= 15228384 |doi= 10.1042/BJ20040681 | pmc=1133971 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Leach NT, Sun Y, Michaud S |title=Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. |journal=Am. J. Hum. Genet. |volume=80 |issue= 4 |pages= 792–9 |year= 2007 |pmid= 17357084 |doi= 10.1086/513019 | pmc=1852716 |display-authors=etal}}

{{refend}}

{{PDB Gallery|geneid=8527}}

{{gene-2-stub}}