DGKZ
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.{{cite journal | vauthors = Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM | title = Molecular cloning and characterization of a novel human diacylglycerol kinase zeta | journal = J Biol Chem | volume = 271 | issue = 17 | pages = 10230–6 |date=Jun 1996 | pmid = 8626588 | doi =10.1074/jbc.271.17.10230 | doi-access = free }}{{cite web | title = Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8525}}
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Interactions
DGKZ has been shown to interact with P110α.{{cite journal |last=Luo |first=Bai |author2=Prescott Stephen M |author3=Topham Matthew K |date=Oct 2003 |title=Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=278 |issue=41 |pages=39542–7 | issn = 0021-9258| pmid = 12890670 |doi = 10.1074/jbc.M307153200 |doi-access=free }}
References
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Further reading
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- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Ding L, Bunting M, Topham MK |title=Alternative splicing of the human diacylglycerol kinase zeta gene in muscle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5519–24 |year= 1997 |pmid= 9159104 |doi=10.1073/pnas.94.11.5519 | pmc=20810 |display-authors=etal|bibcode=1997PNAS...94.5519D|doi-access=free }}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Topham MK, Bunting M, Zimmerman GA |title=Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta |journal=Nature |volume=394 |issue= 6694 |pages= 697–700 |year= 1998 |pmid= 9716136 |doi= 10.1038/29337 |display-authors=etal|bibcode=1998Natur.394..697T |s2cid=204999472 }}
- {{cite journal | vauthors=Liu Z, Chang GQ, Leibowitz SF |title=Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5900–7 |year= 2001 |pmid= 11078732 |doi= 10.1074/jbc.M007311200 |doi-access= free }}
- {{cite journal | vauthors=Topham MK, Prescott SM |title=Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism |journal=J. Cell Biol. |volume=152 |issue= 6 |pages= 1135–43 |year= 2001 |pmid= 11257115 |doi=10.1083/jcb.152.6.1135 | pmc=2199204 }}
- {{cite journal | vauthors=Hogan A, Shepherd L, Chabot J |title=Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26526–33 |year= 2001 |pmid= 11352924 |doi= 10.1074/jbc.M104156200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Santos T, Carrasco S, Jones DR |title=Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30300–9 |year= 2002 |pmid= 12015310 |doi= 10.1074/jbc.M200999200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Zhong XP, Hainey EA, Olenchock BA |title=Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31089–98 |year= 2002 |pmid= 12070163 |doi= 10.1074/jbc.M203818200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Zhong XP, Hainey EA, Olenchock BA |title=Enhanced T cell responses due to diacylglycerol kinase zeta deficiency |journal=Nat. Immunol. |volume=4 |issue= 9 |pages= 882–90 |year= 2003 |pmid= 12883552 |doi= 10.1038/ni958 |s2cid=27265140 |display-authors=etal}}
- {{cite journal | vauthors=Luo B, Prescott SM, Topham MK |title=Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39542–7 |year= 2003 |pmid= 12890670 |doi= 10.1074/jbc.M307153200 |doi-access= free }}
- {{cite journal | vauthors=Abramovici H, Hogan AB, Obagi C |title=Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins |journal=Mol. Biol. Cell |volume=14 |issue= 11 |pages= 4499–511 |year= 2004 |pmid= 14551255 |doi= 10.1091/mbc.E03-03-0190 | pmc=266768 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Davidson L, Pawson AJ, López de Maturana R |title=Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11906–16 |year= 2004 |pmid= 14707140 |doi= 10.1074/jbc.M310784200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Luo B, Prescott SM, Topham MK |title=Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism |journal=Cell. Signal. |volume=16 |issue= 8 |pages= 891–7 |year= 2005 |pmid= 15157668 |doi= 10.1016/j.cellsig.2004.01.010 }}
- {{cite journal | vauthors=Avila-Flores A, Santos T, Rincón E, Mérida I |title=Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10091–9 |year= 2005 |pmid= 15632115 |doi= 10.1074/jbc.M412296200 |doi-access= free }}
- {{cite journal | vauthors=Los AP, Vinke FP, de Widt J |title=The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 858–66 |year= 2006 |pmid= 16286473 |doi= 10.1074/jbc.M502693200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
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