DIS3L2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene.{{cite web

| title = Entrez Gene: DIS3 mitotic control homolog (S. cerevisiae)-like 2

| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=129563

| accessdate = 2013-03-10

}} The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].

Clinical significance

Mutations in DIS3L2 cause Perlman syndrome.{{Cite web|url=https://www.omim.org/entry/267000|title=OMIM Entry - # 267000 - PERLMAN SYNDROME; PRLMNS|website=www.omim.org|access-date=2020-01-25}}

References

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Further reading

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Category:Genes on human chromosome 2

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