DLEU1
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In molecular biology, deleted in lymphocytic leukemia 1 (non-protein coding), also known as DLEU1, is a long non-coding RNA. In humans it is located on chromosome 13q14. The DLEU1 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.{{cite journal | vauthors = Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grandér D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultström AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D | title = Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia | journal = Oncogene | volume = 15 | issue = 20 | pages = 2463–2473 | date = Nov 1997 | pmid = 9395242 | doi = 10.1038/sj.onc.1201643 | s2cid = 21133945 }} It was later discovered to be a long non-coding RNA with over 20 different splice variants.{{cite journal | vauthors = Wolf S, Mertens D, Schaffner C, Korz C, Döhner H, Stilgenbauer S, Lichter P | title = B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions | journal = Human Molecular Genetics | volume = 10 | issue = 12 | pages = 1275–1285 | date = Jun 2001 | pmid = 11406609 | doi = 10.1093/hmg/10.12.1275 | doi-access = free }}
See also
References
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Further reading
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- {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–968 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
- {{cite journal | vauthors = Kapanadze B, Makeeva N, Corcoran M, Jareborg N, Hammarsund M, Baranova A, Zabarovsky E, Vorontsova O, Merup M, Gahrton G, Jansson M, Yankovsky N, Einhorn S, Oscier D, Grandér D, Sangfelt O | title = Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14 | journal = Genomics | volume = 70 | issue = 3 | pages = 327–334 | date = Dec 2000 | pmid = 11161783 | doi = 10.1006/geno.2000.6386 }}
- {{cite journal | vauthors = Mertens D, Philippen A, Ruppel M, Allegra D, Bhattacharya N, Tschuch C, Wolf S, Idler I, Zenz T, Stilgenbauer S | title = Chronic lymphocytic leukemia and 13q14: miRs and more | journal = Leukemia & Lymphoma | volume = 50 | issue = 3 | pages = 502–505 | date = Mar 2009 | pmid = 19347735 | doi = 10.1080/10428190902763509 | s2cid = 9204581 }}
- {{cite journal | vauthors = Polasek O, Marusić A, Rotim K, Hayward C, Vitart V, Huffman J, Campbell S, Janković S, Boban M, Biloglav Z, Kolcić I, Krzelj V, Terzić J, Matec L, Tometić G, Nonković D, Nincević J, Pehlić M, Zedelj J, Velagić V, Juricić D, Kirac I, Belak Kovacević S, Wright AF, Campbell H, Rudan I | title = Genome-wide association study of anthropometric traits in Korcula Island, Croatia | journal = Croatian Medical Journal | volume = 50 | issue = 1 | pages = 7–16 | date = Feb 2009 | pmid = 19260139 | pmc = 2657571 | doi = 10.3325/cmj.2009.50.7 }}
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