DLG2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.{{cite journal | vauthors = Kim E, Cho KO, Rothschild A, Sheng M | title = Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins | journal = Neuron | volume = 17 | issue = 1 | pages = 103–13 | date = December 1996 | pmid = 8755482 | doi = 10.1016/S0896-6273(00)80284-6 | s2cid = 14852857 | doi-access = free }}{{cite journal | vauthors = Stathakis DG, Lee D, Bryant PJ | title = Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110 | journal = Genomics | volume = 54 | issue = 1 | pages = 186–8 | date = January 1999 | pmid = 9806853 | doi = 10.1006/geno.1998.5527 }}
Function
Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.{{cite web | title = Entrez Gene: DLG2 discs, large homolog 2, chapsyn-110 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1740}}
Interactions
DLG2 has been shown to interact with GRIN2B,{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396-403 | date = June 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}{{cite journal | vauthors = Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC | title = Binding of neuroligins to PSD-95 | journal = Science | volume = 277 | issue = 5331 | pages = 1511–5 | date = September 1997 | pmid = 9278515 | doi = 10.1126/science.277.5331.1511 }} KCNJ12.{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 | doi-access = free }}
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M | title = Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. | journal = Nature | volume = 378 | issue = 6552 | pages = 85–8 | year = 1995 | pmid = 7477295 | doi = 10.1038/378085a0 | bibcode = 1995Natur.378...85K | s2cid = 4362906 }}
- {{cite journal | vauthors = Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS | title = Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. | journal = Cell | volume = 84 | issue = 5 | pages = 757–67 | year = 1996 | pmid = 8625413 | doi = 10.1016/S0092-8674(00)81053-3 | s2cid = 15834673 | doi-access = free }}
- {{cite journal | vauthors = Hsueh YP, Kim E, Sheng M | title = Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. | journal = Neuron | volume = 18 | issue = 5 | pages = 803–14 | year = 1997 | pmid = 9182804 | doi = 10.1016/S0896-6273(00)80319-0 | s2cid = 18331544 | doi-access = free }}
- {{cite journal | vauthors = Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M | title = CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. | journal = Neuron | volume = 20 | issue = 4 | pages = 693–707 | year = 1998 | pmid = 9581762 | doi = 10.1016/S0896-6273(00)81009-0 | s2cid = 16068361 | url = https://cdr.lib.unc.edu/downloads/1r66j916h | doi-access = free }}
- {{cite journal | vauthors = Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW | title = SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. | journal = J. Biol. Chem. | volume = 273 | issue = 31 | pages = 19518–24 | year = 1998 | pmid = 9677374 | doi = 10.1074/jbc.273.31.19518 | doi-access = free }}
- {{cite journal | vauthors = Butz S, Okamoto M, Südhof TC | title = A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. | journal = Cell | volume = 94 | issue = 6 | pages = 773–82 | year = 1998 | pmid = 9753324 | doi = 10.1016/S0092-8674(00)81736-5 | s2cid = 12465062 | doi-access = free }}
- {{cite journal | vauthors = Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS | title = Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. | journal = J. Neurosci. | volume = 18 | issue = 21 | pages = 8805–13 | year = 1998 | pmid = 9786987 | doi = 10.1523/JNEUROSCI.18-21-08805.1998| pmc = 6793550 | doi-access = free }}
- {{cite journal | vauthors = Craven SE, El-Husseini AE, Bredt DS | title = Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. | journal = Neuron | volume = 22 | issue = 3 | pages = 497–509 | year = 1999 | pmid = 10197530 | doi = 10.1016/S0896-6273(00)80705-9 | doi-access = free }}
- {{cite journal | vauthors = Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ | title = A developmental change in NMDA receptor-associated proteins at hippocampal synapses. | journal = J. Neurosci. | volume = 20 | issue = 3 | pages = 1260–71 | year = 2000 | pmid = 10648730 | doi = 10.1523/JNEUROSCI.20-03-01260.2000| doi-access = free | pmc = 6774158 }}
- {{cite journal | vauthors = Garcia RA, Vasudevan K, Buonanno A | title = The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 7 | pages = 3596–601 | year = 2000 | pmid = 10725395 | pmc = 16285 | doi = 10.1073/pnas.070042497 | doi-access = free }}
- {{cite journal | vauthors = Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG | title = Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. | journal = Nat. Neurosci. | volume = 3 | issue = 7 | pages = 661–9 | year = 2000 | pmid = 10862698 | doi = 10.1038/76615 | hdl = 1842/742 | s2cid = 14392630 | hdl-access = free }}
- {{cite journal | vauthors = Firestein BL, Craven SE, Bredt DS | title = Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. | journal = NeuroReport | volume = 11 | issue = 16 | pages = 3479–84 | year = 2001 | pmid = 11095503 | doi = 10.1097/00001756-200011090-00016 | s2cid = 19718975 }}
- {{cite journal | vauthors = Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T | title = The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. | journal = Genes Cells | volume = 5 | issue = 11 | pages = 905–911 | year = 2001 | pmid = 11122378 | doi = 10.1046/j.1365-2443.2000.00374.x | s2cid = 37107139 | doi-access = free }}
- {{cite journal | vauthors = DeMarco SJ, Strehler EE | title = Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21594–600 | year = 2001 | pmid = 11274188 | doi = 10.1074/jbc.M101448200 | doi-access = free}}
- {{cite journal | vauthors = Russwurm M, Wittau N, Koesling D | title = Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. | journal = J. Biol. Chem. | volume = 276 | issue = 48 | pages = 44647–52 | year = 2002 | pmid = 11572861 | doi = 10.1074/jbc.M105587200 | doi-access = free }}
- {{cite book | vauthors = Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G | chapter = Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure | title = Protein Expression in Down Syndrome Brain | journal = Journal of Neural Transmission. Supplementum | issue = 61 | pages = 59–70 | year = 2002 | pmid = 11771761 | doi = 10.1007/978-3-7091-6262-0_5| isbn = 978-3-211-83704-7 }}
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{{PDB Gallery|geneid=1740}}