DLG2

Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.{{cite web | title = Entrez Gene: DLG2 discs, large homolog 2, chapsyn-110 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1740}}

DLG2 has been shown to interact with GRIN2B,{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396-403 | date = June 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}{{cite journal | vauthors = Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC | title = Binding of neuroligins to PSD-95 | journal = Science | volume = 277 | issue = 5331 | pages = 1511–5 | date = September 1997 | pmid = 9278515 | doi = 10.1126/science.277.5331.1511 }} KCNJ12.{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 | doi-access = free }}

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• {{cite book | vauthors = Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G | chapter = Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure | title = Protein Expression in Down Syndrome Brain | journal = Journal of Neural Transmission. Supplementum | issue = 61 | pages = 59–70 | year = 2002 | pmid = 11771761 | doi = 10.1007/978-3-7091-6262-0_5| isbn = 978-3-211-83704-7 }}

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{{PDB Gallery|geneid=1740}}

Category:Genes mutated in mice