DLG3

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{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene.{{cite journal | vauthors = Stathakis DG, Lee D, Bryant PJ | title = DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1 | journal = Genomics | volume = 49 | issue = 2 | pages = 310–3 |date=Aug 1998 | pmid = 9598320 | doi = 10.1006/geno.1998.5243 }}{{cite web | title = Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1741}} DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Interactions

DLG3 has been shown to interact with:

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  • APC,{{cite journal | date = May 1997 | vauthors = Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H | title = Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein | journal = Oncogene | volume = 14 | issue = 20 | pages = 2425–33 | pmid = 9188857 | doi = 10.1038/sj.onc.1201087| s2cid = 6554126 | doi-access = }}
  • CRIPT,
  • DLG4,{{cite journal | date = Feb 1999 | vauthors = Masuko N, Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H | title = Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5782–90 | pmid = 10026200 | doi = 10.1074/jbc.274.9.5782| doi-access = free }}
  • EXOC3,
  • EXOC4,
  • GRIN2A,{{cite journal | date = Sep 1997 | vauthors = Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC | title = Binding of neuroligins to PSD-95 | journal = Science | volume = 277 | issue = 5331 | pages = 1511–5 | pmid = 9278515 | doi = 10.1126/science.277.5331.1511}}
  • GRIN2B,{{cite journal | date = Jun 2003 | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | pmid = 12738960 | doi = 10.1038/ncb990| s2cid = 13444388 }}{{cite journal | date = Jun 2002 | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396-403 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001}}
  • GRIN2C,{{cite journal | date = Jun 2002 | vauthors = Lim IA, Hall DD, Hell JW | title = Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 | journal = J. Biol. Chem. | volume = 277 | issue = 24 | pages = 21697–711 | pmid = 11937501 | doi = 10.1074/jbc.M112339200| doi-access = free }}
  • KCNJ12{{cite journal | date = May 2004 | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | pmid = 15024025 | doi = 10.1074/jbc.M400285200| doi-access = free }}
  • PTK2B,{{cite journal | date = Apr 2003 | vauthors = Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW | title = Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15040–8 | pmid = 12576483 | doi = 10.1074/jbc.M212825200| doi-access = free }} and
  • SYNGAP1.{{cite journal | date = Apr 1998 | vauthors = Kim JH, Liao D, Lau LF, Huganir RL | title = SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family | journal = Neuron | volume = 20 | issue = 4 | pages = 683–91 | pmid = 9581761 | doi = 10.1016/S0896-6273(00)81008-9| doi-access = free }}

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References

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Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Lau LF, Mammen A, Ehlers MD |title=Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21622–8 |year= 1996 |pmid= 8702950 |doi=10.1074/jbc.271.35.21622 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Müller BM, Kistner U, Kindler S |title=SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. |journal=Neuron |volume=17 |issue= 2 |pages= 255–65 |year= 1996 |pmid= 8780649 |doi=10.1016/S0896-6273(00)80157-9 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Takeuchi M, Hata Y, Hirao K |title=SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11943–51 |year= 1997 |pmid= 9115257 |doi=10.1074/jbc.272.18.11943 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Makino K, Kuwahara H, Masuko N |title=Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. |journal=Oncogene |volume=14 |issue= 20 |pages= 2425–33 |year= 1997 |pmid= 9188857 |doi= 10.1038/sj.onc.1201087 |s2cid=6554126 |display-authors=etal|doi-access= }}
  • {{cite journal | vauthors=Irie M, Hata Y, Takeuchi M |title=Binding of neuroligins to PSD-95. |journal=Science |volume=277 |issue= 5331 |pages= 1511–5 |year= 1997 |pmid= 9278515 |doi=10.1126/science.277.5331.1511 |display-authors=etal}}
  • {{cite journal | vauthors=Kim JH, Liao D, Lau LF, Huganir RL |title=SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. |journal=Neuron |volume=20 |issue= 4 |pages= 683–91 |year= 1998 |pmid= 9581761 |doi=10.1016/S0896-6273(00)81008-9 |doi-access=free }}
  • {{cite journal | vauthors=Butz S, Okamoto M, Südhof TC |title=A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. |journal=Cell |volume=94 |issue= 6 |pages= 773–82 |year= 1998 |pmid= 9753324 |doi=10.1016/S0092-8674(00)81736-5 |doi-access=free }}
  • {{cite journal | vauthors=Garcia EP, Mehta S, Blair LA |title=SAP90 binds and clusters kainate receptors causing incomplete desensitization. |journal=Neuron |volume=21 |issue= 4 |pages= 727–39 |year= 1998 |pmid= 9808460 |doi=10.1016/S0896-6273(00)80590-5 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Masuko N, Makino K, Kuwahara H |title=Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5782–90 |year= 1999 |pmid= 10026200 |doi=10.1074/jbc.274.9.5782 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Kuwahara H, Araki N, Makino K |title=A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32204–14 |year= 1999 |pmid= 10542258 |doi=10.1074/jbc.274.45.32204 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Nagase T, Ishikawa K, Kikuno R |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Firestein BL, Firestein BL, Brenman JE |title=Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. |journal=Neuron |volume=24 |issue= 3 |pages= 659–72 |year= 2000 |pmid= 10595517 |doi=10.1016/S0896-6273(00)81120-4 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Garcia RA, Vasudevan K, Buonanno A |title=The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3596–601 |year= 2000 |pmid= 10725395 |doi= 10.1073/pnas.070042497 | pmc=16285 |doi-access=free }}
  • {{cite journal | vauthors=Husi H, Ward MA, Choudhary JS |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 |display-authors=etal|hdl=1842/742 |s2cid=14392630 |hdl-access=free }}
  • {{cite journal | vauthors=Inagaki S, Ohoka Y, Sugimoto H |title=Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9174–81 |year= 2001 |pmid= 11134026 |doi= 10.1074/jbc.M009051200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=DeMarco SJ, Strehler EE |title=Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21594–600 |year= 2001 |pmid= 11274188 |doi= 10.1074/jbc.M101448200 |doi-access=free }}
  • {{cite journal | vauthors=Russwurm M, Wittau N, Koesling D |title=Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44647–52 |year= 2002 |pmid= 11572861 |doi= 10.1074/jbc.M105587200 |doi-access= free }}
  • {{cite journal | vauthors=Lim IA, Hall DD, Hell JW |title=Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21697–711 |year= 2002 |pmid= 11937501 |doi= 10.1074/jbc.M112339200 |doi-access= free }}
  • {{cite journal | vauthors=Cai C, Coleman SK, Niemi K, Keinänen K |title=Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31484–90 |year= 2002 |pmid= 12070168 |doi= 10.1074/jbc.M204354200 |doi-access= free }}

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