DLGAP5
{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.{{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 | journal = DNA Res | volume = 1 | issue = 1 | pages = 27–35 |date=Dec 1995 | pmid = 7584026 | doi =10.1093/dnares/1.1.27 | doi-access = free }}{{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) | journal = DNA Res | volume = 1 | issue = 1 | pages = 47–56 |date=Dec 1995 | pmid = 7584028 | doi =10.1093/dnares/1.1.47 | doi-access = free }}{{cite web | title = Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9787}}{{cite journal | vauthors = Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ | title = Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1 | journal = Genomics | volume = 77 | issue = 1–2 | pages = 5–7 |date=September 2001 | pmid = 11543626 | doi = 10.1006/geno.2001.6570 }}
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.{{cite journal | author = Wilde A | title = "HURP on" we're off to the kinetochore! | journal = J. Cell Biol. | volume = 173 | issue = 6 | pages = 829–31 |date=June 2006 | pmid = 16785318 | pmc = 2063907 | doi = 10.1083/jcb.200605150 }} DGL7 is a part of Ran-dependent complex.{{cite journal | vauthors = Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW | title = HURP is part of a Ran-dependent complex involved in spindle formation | journal = Curr. Biol. | volume = 16 | issue = 8 | pages = 743–54 |date=April 2006 | pmid = 16631581 | doi = 10.1016/j.cub.2006.03.056 | doi-access = free | bibcode = 2006CBio...16..743K }} Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.{{cite journal | vauthors = Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY | title = Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A | journal = Mol. Cell. Biol. | volume = 25 | issue = 14 | pages = 5789–800 |date=July 2005 | pmid = 15987997 | pmc = 1168800 | doi = 10.1128/MCB.25.14.5789-5800.2005 }} Expression of DGL7 is found in cancer{{cite journal | vauthors = Sanderson HS, Clarke PR | title = Cell biology: Ran, mitosis and the cancer connection | journal = Curr. Biol. | volume = 16 | issue = 12 | pages = R466–8 |date=June 2006 | pmid = 16782004 | doi = 10.1016/j.cub.2006.05.032 | doi-access = free | bibcode = 2006CBio...16.R466S }} and stem cells.{{cite journal | vauthors = Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE | title = Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene | journal = Stem Cells | volume = 25 | issue = 6 | pages = 1498–506 |date=June 2007 | pmid = 17322106 | doi = 10.1634/stemcells.2005-0479 | s2cid = 25347875 |display-authors=etal}}
References
{{Reflist|2}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Ohara O, Nagase T, Ishikawa K |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=10.1093/dnares/4.1.53 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Bassal S, Nomura N, Venter D |title=Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1 |journal=Genomics |volume=77 |issue= 1–2 |pages= 5–7 |year= 2001 |pmid= 11543626 |doi= 10.1006/geno.2001.6570 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Tsou AP, Yang CW, Huang CY |title=Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma |journal=Oncogene |volume=22 |issue= 2 |pages= 298–307 |year= 2003 |pmid= 12527899 |doi= 10.1038/sj.onc.1206129 |s2cid=24615395 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Mantovani F, Banks L |title=Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42477–86 |year= 2004 |pmid= 12902344 |doi= 10.1074/jbc.M302799200 |doi-access= free }}
- {{cite journal | vauthors=Laprise P, Viel A, Rivard N |title=Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10157–66 |year= 2004 |pmid= 14699157 |doi= 10.1074/jbc.M309843200 |doi-access= free }}
- {{cite journal | vauthors=Shu H, Chen S, Bi Q |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line |journal=Mol. Cell. Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Hsu JM, Lee YC, Yu CT, Huang CY |title=Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32592–602 |year= 2004 |pmid= 15145941 |doi= 10.1074/jbc.M404950200 |doi-access= free }}
- {{cite journal | vauthors=Blot V, Delamarre L, Perugi F |title=Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes |journal=J. Cell Sci. |volume=117 |issue= Pt 17 |pages= 3983–93 |year= 2005 |pmid= 15286176 |doi= 10.1242/jcs.01266 |s2cid=23757741 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Zhao L, Qin LX, Ye QH |title=KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis |journal=J. Cancer Res. Clin. Oncol. |volume=130 |issue= 12 |pages= 719–27 |year= 2005 |pmid= 15340842 |doi= 10.1007/s00432-004-0595-2 |s2cid=24151704 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Yu CT, Hsu JM, Lee YC |title=Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5789–800 |year= 2005 |pmid= 15987997 |doi= 10.1128/MCB.25.14.5789-5800.2005 | pmc=1168800 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
- {{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Wong J, Fang G |title=HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture |journal=J. Cell Biol. |volume=173 |issue= 6 |pages= 879–91 |year= 2006 |pmid= 16769820 |doi= 10.1083/jcb.200511132 | pmc=2063914 }}
- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }}
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External links
- {{MeshName|DLG7+protein,+human|3=DLG7 protein, human}}
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