DLL4
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.{{cite journal | vauthors = Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL | title = Dll4, a novel Notch ligand expressed in arterial endothelium | journal = Genes & Development | volume = 14 | issue = 11 | pages = 1313–8 | date = June 2000 | pmid = 10837024 | pmc = 316657 | doi = 10.1101/gad.14.11.1313 }}{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567}}
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
References
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Further reading
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- {{cite journal | vauthors = Yoneya T, Tahara T, Nagao K, Yamada Y, Yamamoto T, Osawa M, Miyatani S, Nishikawa M | title = Molecular cloning of delta-4, a new mouse and human Notch ligand | journal = Journal of Biochemistry | volume = 129 | issue = 1 | pages = 27–34 | date = January 2001 | pmid = 11134954 | doi = 10.1093/oxfordjournals.jbchem.a002832 }}
- {{cite journal | vauthors = Yan XQ, Sarmiento U, Sun Y, Huang G, Guo J, Juan T, Van G, Qi MY, Scully S, Senaldi G, Fletcher FA | title = A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer | journal = Blood | volume = 98 | issue = 13 | pages = 3793–9 | date = December 2001 | pmid = 11739188 | doi = 10.1182/blood.V98.13.3793 | doi-access = free }}
- {{cite journal | vauthors = Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D | title = Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis | journal = Differentiation; Research in Biological Diversity | volume = 69 | issue = 2–3 | pages = 135–44 | date = December 2001 | pmid = 11798067 | doi = 10.1046/j.1432-0436.2001.690207.x }}
- {{cite journal | vauthors = Dorsch M, Zheng G, Yowe D, Rao P, Wang Y, Shen Q, Murphy C, Xiong X, Shi Q, Gutierrez-Ramos JC, Fraser C, Villeval JL | title = Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease | journal = Blood | volume = 100 | issue = 6 | pages = 2046–55 | date = September 2002 | pmid = 12200365 | doi = 10.1182/blood.V100.6.2046| doi-access = free }}
- {{cite journal | vauthors = Liu ZJ, Shirakawa T, Li Y, Soma A, Oka M, Dotto GP, Fairman RM, Velazquez OC, Herlyn M | title = Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis | journal = Molecular and Cellular Biology | volume = 23 | issue = 1 | pages = 14–25 | date = January 2003 | pmid = 12482957 | pmc = 140667 | doi = 10.1128/MCB.23.1.14-25.2003 }}
- {{cite journal | vauthors = Tohda S, Murata-Ohsawa M, Sakano S, Nara N | title = Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines | journal = International Journal of Oncology | volume = 22 | issue = 5 | pages = 1073–9 | date = May 2003 | pmid = 12684674 | doi = 10.3892/ijo.22.5.1073 }}
- {{cite journal | vauthors = Shawber CJ, Das I, Francisco E, Kitajewski J | title = Notch signaling in primary endothelial cells | journal = Annals of the New York Academy of Sciences | volume = 995 | issue = 1| pages = 162–70 | date = May 2003 | pmid = 12814948 | doi = 10.1111/j.1749-6632.2003.tb03219.x | bibcode = 2003NYASA.995..162S | s2cid = 25058168 }}
- {{cite journal | vauthors = Lauret E, Catelain C, Titeux M, Poirault S, Dando JS, Dorsch M, Villeval JL, Groseil A, Vainchenker W, Sainteny F, Bennaceur-Griscelli A | title = Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential | journal = Leukemia | volume = 18 | issue = 4 | pages = 788–97 | date = April 2004 | pmid = 14990974 | doi = 10.1038/sj.leu.2403288 | s2cid = 6608609 | doi-access = }}
- {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
- {{cite journal | vauthors = McKeane DP, Meyer J, Dobrin SE, Melmed KM, Ekawardhani S, Tracy NA, Lesch KP, Stephan DA | title = No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families | journal = Schizophrenia Research | volume = 75 | issue = 1 | pages = 1–3 | date = June 2005 | pmid = 15820317 | doi = 10.1016/j.schres.2004.07.017 | s2cid = 42665216 }}
- {{cite journal | vauthors = Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL | title = Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function | journal = Cancer Research | volume = 65 | issue = 19 | pages = 8690–7 | date = October 2005 | pmid = 16204037 | doi = 10.1158/0008-5472.CAN-05-1208 | doi-access = free | hdl = 10026.1/10306 | hdl-access = free }}
- {{cite journal | vauthors = Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li JL, Harris AL | title = Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer | journal = Clinical Cancer Research | volume = 12 | issue = 16 | pages = 4836–44 | date = August 2006 | pmid = 16914569 | doi = 10.1158/1078-0432.CCR-06-0285 | doi-access = free }}
- {{cite journal | vauthors = Lefort N, Benne C, Lelièvre JD, Dorival C, Balbo M, Sakano S, Coulombel L, Lévy Y | title = Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells | journal = Experimental Hematology | volume = 34 | issue = 12 | pages = 1720–9 | date = December 2006 | pmid = 17157169 | doi = 10.1016/j.exphem.2006.08.007 | doi-access = free }}
- {{cite journal | vauthors = Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M | title = Delta-like 4 induces notch signaling in macrophages: implications for inflammation | journal = Circulation | volume = 115 | issue = 23 | pages = 2948–56 | date = June 2007 | pmid = 17533181 | doi = 10.1161/CIRCULATIONAHA.106.675462 | s2cid = 12333385 | doi-access = }}
- {{cite journal | vauthors = Hodkinson PS, Elliott PA, Lad Y, McHugh BJ, MacKinnon AC, Haslett C, Sethi T | title = Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras | journal = The Journal of Biological Chemistry | volume = 282 | issue = 39 | pages = 28991–9001 | date = September 2007 | pmid = 17664272 | doi = 10.1074/jbc.M703601200 | doi-access = free | hdl = 1842/4393 | hdl-access = free }}
- {{cite journal | vauthors = Zang S, Ji C, Qu X, Dong X, Ma D, Ye J, Ma R, Dai J, Guo D | title = A study on Notch signaling in human breast cancer | journal = Neoplasma | volume = 54 | issue = 4 | pages = 304–10 | year = 2007 | pmid = 17822320 }}
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External links
- {{PDBe-KB2|Q9NR61|Delta-like protein 4}}
{{Notch signaling pathway}}
{{gene-15-stub}}