DLST
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DLST gene.{{cite journal | vauthors = Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP | title = Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex | journal = Somat Cell Mol Genet | volume = 20 | issue = 2 | pages = 99–105 |date=Jul 1994 | pmid = 8009371 | doi =10.1007/BF02290679 | s2cid = 43092605 }}{{cite web | title = Entrez Gene: DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1743}}
Interactive pathway map
{{TCACycle_WP78|highlight=DLST}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Chuang DT, Fisher CW, Lau KS |title=Maple syrup urine disease: domain structure, mutations and exon skipping in the dihydrolipoyl transacylase (E2) component of the branched-chain alpha-keto acid dehydrogenase complex. |journal=Mol. Biol. Med. |volume=8 |issue= 1 |pages= 49–63 |year= 1991 |pmid= 1943690 |display-authors=etal}}
- {{cite journal | vauthors=Fregeau DR, Prindiville T, Coppel RL |title=Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis. |journal=Hepatology |volume=11 |issue= 6 |pages= 975–81 |year= 1990 |pmid= 2365294 |doi=10.1002/hep.1840110611 |s2cid=83760368 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ono K, Hakozaki M, Kimura A, Kochi H |title=Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex. |journal=J. Biochem. |volume=101 |issue= 1 |pages= 19–27 |year= 1987 |pmid= 3571202 |doi= 10.1093/oxfordjournals.jbchem.a121891|doi-access= free }}
- {{cite journal | vauthors=Kochi H, Seino H, Ono K |title=Inhibition of glycine oxidation by pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids in rat liver mitochondria: presence of interaction between the glycine cleavage system and alpha-keto acid dehydrogenase complexes. |journal=Arch. Biochem. Biophys. |volume=249 |issue= 2 |pages= 263–72 |year= 1986 |pmid= 3753002 |doi=10.1016/0003-9861(86)90002-0 }}
- {{cite journal | vauthors=Nakano K, Takase C, Sakamoto T |title=Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. |journal=Eur. J. Biochem. |volume=224 |issue= 1 |pages= 179–89 |year= 1994 |pmid= 8076640 |doi=10.1111/j.1432-1033.1994.tb20010.x |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Nakano K, Takase C, Sakamoto T |title=An unspliced cDNA for human dihydrolipoamide succinyltransferase: characterization and mapping of the gene to chromosome 14q24.2-q24.3. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 2 |pages= 527–33 |year= 1993 |pmid= 8240324 |doi= 10.1006/bbrc.1993.2282 |display-authors=etal}}
- {{cite journal | vauthors=Nakano K, Matuda S, Sakamoto T |title=Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. |journal=Biochim. Biophys. Acta |volume=1216 |issue= 3 |pages= 360–8 |year= 1994 |pmid= 8268217 |doi= 10.1016/0167-4781(93)90002-u|display-authors=etal}}
- {{cite journal | vauthors=Cruts M, Backhovens H, Van Gassen G |title=Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease. |journal=Neurosci. Lett. |volume=199 |issue= 1 |pages= 73–7 |year= 1996 |pmid= 8584231 |doi=10.1016/0304-3940(95)11982-3 |display-authors=etal|url=http://repub.eur.nl/pub/72164 |hdl=1765/72164 |s2cid=7439684 |hdl-access=free }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal | vauthors=Matuda S, Kodama J, Goshi N |title=A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 1 |pages= 151–6 |year= 1998 |pmid= 9405249 |doi= 10.1006/bbrc.1997.7784 |display-authors=etal}}
- {{cite journal | vauthors=McCartney RG, Rice JE, Sanderson SJ |title=Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24158–64 |year= 1998 |pmid= 9727038 |doi=10.1074/jbc.273.37.24158 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Sheu KF, Brown AM, Haroutunian V |title=Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. |journal=Ann. Neurol. |volume=45 |issue= 1 |pages= 48–53 |year= 1999 |pmid= 9894876 |doi=10.1002/1531-8249(199901)45:1<48::AID-ART9>3.0.CO;2-V |s2cid=40038247 |display-authors=etal}}
- {{cite journal | vauthors=Ma Q, Chan P, Yang J |title=[Association between DLST gene polymorphism and Alzheimer's disease] |journal=Zhonghua Yi Xue Za Zhi |volume=81 |issue= 20 |pages= 1246–8 |year= 2002 |pmid= 11825528 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Kanamori T, Nishimaki K, Asoh S |title=Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain |journal=EMBO J. |volume=22 |issue= 12 |pages= 2913–23 |year= 2003 |pmid= 12805207 |doi= 10.1093/emboj/cdg299 | pmc=162151 |display-authors=etal}}
- {{cite journal | vauthors=Brown AM, Gordon D, Lee H |title=Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association |journal=Neurochem. Res. |volume=29 |issue= 3 |pages= 629–35 |year= 2004 |pmid= 15038610 |doi=10.1023/B:NERE.0000014833.54481.1d |s2cid=35438569 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|hdl=11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access=free }}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
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{{Multienzyme complexes}}
Category:Mitochondrial proteins
{{gene-14-stub}}