DLX1

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Letinic K, Zoncu R, Rakic P | title = Origin of GABAergic neurons in the human neocortex. | journal = Nature | volume = 417 | issue = 6889 | pages = 645–9 | year = 2002 | pmid = 12050665 | doi = 10.1038/nature00779 | bibcode = 2002Natur.417..645L | s2cid = 4349070 }}
• {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 | year = 2003 | pmid = 12477932 | doi = 10.1073/pnas.242603899 | pmc = 139241 | bibcode = 2002PNAS...9916899M |display-authors=etal| doi-access = free }}
• {{cite journal | vauthors = Chiba S, Takeshita K, Imai Y | title = Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 26 | pages = 15577–82 | year = 2004 | pmid = 14671321 | doi = 10.1073/pnas.2536757100 | pmc = 307610 |display-authors=etal| doi-access = free }}
• {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T | title = Complete sequencing and characterization of 21,243 full-length human cDNAs. | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–5 | year = 2004 | pmid = 14702039 | doi = 10.1038/ng1285 |display-authors=etal| doi-access = free }}
• {{cite journal | vauthors = Zhou QP, Le TN, Qiu X | title = Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. | journal = Nucleic Acids Res. | volume = 32 | issue = 3 | pages = 884–92 | year = 2004 | pmid = 14769946 | doi = 10.1093/nar/gkh233 | pmc = 373381 |display-authors=etal}}
• {{cite journal | vauthors = Gerhard DS, Wagner L, Feingold EA | title = The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–7 | year = 2004 | pmid = 15489334 | doi = 10.1101/gr.2596504 | pmc = 528928 |display-authors=etal}}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 |display-authors=etal}}
• {{cite journal | vauthors = Hamilton SP, Woo JM, Carlson EJ | title = Analysis of four DLX homeobox genes in autistic probands. | journal = BMC Genet. | volume = 6 | pages = 52 | year = 2006 | pmid = 16266434 | doi = 10.1186/1471-2156-6-52 | pmc = 1310613 |display-authors=etal | doi-access = free }}

{{refend}}

{{Transcription factors and intracellular receptors|g3}}

{{gene-2-stub}}