DLX4

Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of the beta-globin gene while the other isoform lacks that function.

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• {{cite journal | author=Nakamura S |title=Genomic analysis of a new mammalian distal-less gene: Dlx7 |journal=Genomics |volume=38 |issue= 3 |pages= 314–24 |year= 1997 |pmid= 8975708 |doi= 10.1006/geno.1996.0634 | author2=Stock DW | author3=Wydner KL | last4=Bollekens | first4=Jacques A. | last5=Takeshita | first5=Kenichi | last6=Nagai | first6=Brian M. | last7=Chiba | first7=Shigeru | last8=Kitamura | first8=Toshio | last9=Freeland | first9=Thomas M. | doi-access=free }}
• {{cite journal | author=Quinn LM |title=Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4 |journal=Gene |volume=187 |issue= 1 |pages= 55–61 |year= 1997 |pmid= 9073066 |doi=10.1016/S0378-1119(96)00706-8 | author2=Johnson BV | author3=Nicholl J | last4=Sutherland | first4=GR | last5=Kalionis | first5=B }}
• {{cite journal | vauthors=Morasso MI, Yonescu R, Griffin CA, Sargent TD |title=Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization |journal=Mamm. Genome |volume=8 |issue= 4 |pages= 302–3 |year= 1997 |pmid= 9096128 |doi=10.1007/s003359900427 |s2cid=7448287 }}
• {{cite journal | author=Price JA |title=Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 563–9 |year= 1998 |pmid= 9467018 |doi=10.1093/hmg/7.3.563 | author2=Bowden DW | author3=Wright JT | last4=Pettenati | first4=MJ | last5=Hart | first5=TC |doi-access=free}}
• {{cite journal | vauthors=Quinn LM, Latham SE, Kalionis B |title=A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta |journal=Placenta |volume=19 |issue= 1 |pages= 87–93 |year= 1998 |pmid= 9481790 |doi=10.1016/S0143-4004(98)90103-5 }}
• {{cite journal | vauthors=Quinn LM, Kilpatrick LM, Latham SE, Kalionis B |title=Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium |journal=Mol. Hum. Reprod. |volume=4 |issue= 5 |pages= 497–501 |year= 1998 |pmid= 9665637 |doi=10.1093/molehr/4.5.497 |doi-access=free }}
• {{cite journal | vauthors=Quinn LM, Latham SE, Kalionis B |title=The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta |journal=Placenta |volume=21 Suppl A |pages= S50–4 |year= 2000 |pmid= 10831122 |doi= 10.1053/plac.1999.0514}}
• {{cite journal | author=Haga SB |title=BP1, a new homeobox gene, is frequently expressed in acute leukemias |journal=Leukemia |volume=14 |issue= 11 |pages= 1867–75 |year= 2000 |pmid= 11069021 |doi=10.1038/sj.leu.2401912 | author2=Fu S | author3=Karp JE | last4=Ross | first4=D D | last5=Williams | first5=D M | last6=Hankins | first6=W D | last7=Behm | first7=F | last8=Ruscetti | first8=F W | last9=Chang | first9=M |s2cid=24099984 | doi-access= }}
• {{cite journal | author=Masuda Y |title=Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5331–8 |year= 2001 |pmid= 11084035 |doi= 10.1074/jbc.M008590200 | author2=Sasaki A | author3=Shibuya H | last4=Ueno | first4=N | last5=Ikeda | first5=K | last6=Watanabe | first6=K | doi-access=free}}
• {{cite journal | author=Fu S |title=Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene |journal=Gene |volume=278 |issue= 1–2 |pages= 131–9 |year= 2002 |pmid= 11707330 |doi=10.1016/S0378-1119(01)00716-8 | author2=Stevenson H | author3=Strovel JW | last4=Haga | first4=SB | last5=Stamberg | first5=J | last6=Do | first6=K | last7=Berg | first7=PE }}
• {{cite journal | author=Sumiyama K |title=Genomic structure and functional control of the Dlx3-7 bigene cluster |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 780–5 |year= 2002 |pmid= 11792834 |doi= 10.1073/pnas.012584999 | pmc=117382 | author2=Irvine SQ | author3=Stock DW | last4=Weiss | first4=KM | last5=Kawasaki | first5=K | last6=Shimizu | first6=N | last7=Shashikant | first7=CS | last8=Miller | first8=W | last9=Ruddle | first9=FH |bibcode=2002PNAS...99..780S |doi-access=free }}
• {{cite journal | author=Chase MB |title=BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2505–14 |year= 2002 |pmid= 11909945 |doi=10.1128/MCB.22.8.2505-2514.2002 | pmc=133721 | author2=Fu S | author3=Haga SB | last4=Davenport | first4=G. | last5=Stevenson | first5=H. | last6=Do | first6=K. | last7=Morgan | first7=D. | last8=Mah | first8=A. L. | last9=Berg | first9=P. E. }}
• {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal | author=Neufing PJ |title=Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues |journal=Anticancer Res. |volume=23 |issue= 2B |pages= 1479–88 |year= 2003 |pmid= 12820413 | author2=Kalionis B | author3=Horsfall DJ | last4=Ricciardelli | first4=C | last5=Stahl | first5=J | last6=Vivekanandan | first6=S | last7=Raymond | first7=W | last8=Tilley | first8=WD }}
• {{cite journal | vauthors=Zoueva OP, Rodgers GP |title=Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line |journal=Exp. Hematol. |volume=32 |issue= 8 |pages= 700–8 |year= 2004 |pmid= 15308321 |doi= 10.1016/j.exphem.2004.05.024 |url=https://zenodo.org/record/1258931 |doi-access=free }}
• {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
• {{cite journal | author=Mpollo MS |title=BP1 is a negative modulator of definitive erythropoiesis |journal=Nucleic Acids Res. |volume=34 |issue= 18 |pages= 5232–7 |year= 2006 |pmid= 17003054 |doi= 10.1093/nar/gkl680 | pmc=1636446 | author2=Beaudoin M | author3=Berg PE | last4=Beauchemin | first4=H. | last5=d'Agati | first5=V. | last6=Trudel | first6=M. }}
• {{cite journal | author=Murthi P |title=Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction |journal=Mol. Hum. Reprod. |volume=12 |issue= 12 |pages= 763–9 |year= 2007 |pmid= 17062780 |doi= 10.1093/molehr/gal087 | author2=Said JM | author3=Doherty VL | last4=Donath | first4=S. | last5=Nowell | first5=C.J. | last6=Brennecke | first6=S.P. | last7=Kalionis | first7=B. | doi-access= }}
• {{cite journal | author=Tomida S |title=Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach |journal=Oncogene |volume=26 |issue= 31 |pages= 4600–8 |year= 2007 |pmid= 17260014 |doi= 10.1038/sj.onc.1210242 | author2=Yanagisawa K | author3=Koshikawa K | last4=Yatabe | first4=Y | last5=Mitsudomi | first5=T | last6=Osada | first6=H | last7=Takahashi | first7=T | doi-access=free }}

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• {{MeshName|DLX4+protein,+human}}

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{{Transcription factors|g3}}

Category:Transcription factors

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