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DLX6

{{Short description|Mammalian protein found in Homo sapiens}}

{{Infobox_gene}}

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.{{cite journal | vauthors = Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K | title = Cloning and characterization of two members of the vertebrate Dlx gene family | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 6 | pages = 2250–4 |date=Apr 1994 | pmid = 7907794 | pmc = 43348 | doi =10.1073/pnas.91.6.2250 | bibcode = 1994PNAS...91.2250S |display-authors=etal| doi-access = free }}{{cite web | title = Entrez Gene: DLX6 distal-less homeobox 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1750}}

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family, DLX5, on the long arm of chromosome 7.

References

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Further reading

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  • {{cite journal | vauthors=Crackower MA, Scherer SW, Rommens JM |title=Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 571–9 |year= 1997 |pmid= 8733122 |doi=10.1093/hmg/5.5.571 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Charité J, McFadden DG, Merlo G |title=Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. |journal=Genes Dev. |volume=15 |issue= 22 |pages= 3039–49 |year= 2001 |pmid= 11711438 |doi= 10.1101/gad.931701 | pmc=312822 |display-authors=etal}}
  • {{cite journal | vauthors=Depew MJ, Lufkin T, Rubenstein JL |title=Specification of jaw subdivisions by Dlx genes. |journal=Science |volume=298 |issue= 5592 |pages= 381–5 |year= 2002 |pmid= 12193642 |doi= 10.1126/science.1075703 |s2cid=10274300 |doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Nabi R, Zhong H, Serajee FJ, Huq AH |title=No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=119 |issue= 1 |pages= 98–101 |year= 2004 |pmid= 12707945 |doi= 10.1002/ajmg.b.10012 |s2cid=39985829 |doi-access=free }}
  • {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Schüle B, Li HH, Fisch-Kohl C |title=DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. |journal=Am. J. Hum. Genet. |volume=81 |issue= 3 |pages= 492–506 |year= 2007 |pmid= 17701895 |doi= 10.1086/520063 | pmc=1950824 |display-authors=etal}}

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{{Transcription factors and intracellular receptors|g3}}

{{gene-7-stub}}