DNA-formamidopyrimidine glycosylase

{{Infobox enzyme

| Name = DNA-formamidopyrimidine glycosylase

| EC_number = 3.2.2.23

| CAS_number = 78783-53-6

| GO_code =

| image =

| width =

| caption =

}}

DNA-formamidopyrimidine glycosylase ({{EC number|3.2.2.23}}, Fapy-DNA glycosylase, deoxyribonucleate glycosidase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase, DNA-formamidopyrimidine glycosidase, Fpg protein) is an enzyme with systematic name DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing).{{cite journal | vauthors = Boiteux S, O'Connor TR, Laval J | title = Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein | journal = The EMBO Journal | volume = 6 | issue = 10 | pages = 3177–83 | date = October 1987 | pmid = 3319582 | pmc = 553760 }} FPG is a base excision repair enzyme which recognizes and removes a wide range of oxidized purines from correspondingly damaged DNA.{{cite journal | author=Serre1 | title=Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA | journal=The EMBO Journal | volume=21 | issue=12 | year=2002 | pages=2854–2865 | doi=10.1093/emboj/cdf304 | pmid=12065399 | last2=Pereira De Jésus | first2=K | last3=Boiteux | first3=S | last4=Zelwer | first4=C | last5=Castaing | first5=B | pmc=126059|display-authors=etal}} It was discovered by Zimbabwean scientist Christopher J. Chetsanga in 1975.{{cite journal | author = Chetsanga C.J., Lindahl T. | year = 1979 | title = Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli | journal = Nucleic Acids Res | volume = 6 | issue = 11| pages = 3673–84 | doi = 10.1093/nar/6.11.3673 | pmid = 386277 | pmc = 327965 }}

This enzyme catalyses the following chemical reaction

: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine

This enzyme participates in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.