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DNA2L

{{Short description|Protein-coding gene in the species Homo sapiens}}

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DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.{{cite journal | vauthors = Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F | title = Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1 | journal = Genomics | volume = 37 | issue = 3 | pages = 408–10 |date=Mar 1997 | pmid = 8938459 | doi = 10.1006/geno.1996.0581 }}{{cite journal | vauthors = Masuda-Sasa T, Polaczek P, Campbell JL | title = Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation | journal = J Biol Chem | volume = 281 | issue = 50 | pages = 38555–64 |date=Dec 2006 | pmid = 17032657 | doi = 10.1074/jbc.M604925200 | doi-access = free }}{{cite web | title = Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1763}} Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.{{cite journal | title=Nucleases and helicases take center stage in homologous recombination | journal=Trends in Biochemical Sciences | last1=Mimitou | first1=EP | last2=Symington | first2=LS |date=May 2009 | volume=34 | issue=5 | pages=264–272 | doi=10.1016/j.tibs.2009.01.010 | pmid=19375328}}

References

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Further reading

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  • {{cite journal | vauthors=Masuda-Sasa T, Imamura O, Campbell JL |title=Biochemical analysis of human Dna2 |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1865–75 |year= 2006 |pmid= 16595800 |doi= 10.1093/nar/gkl070 | pmc=1428797 }}
  • {{cite journal | vauthors=Kim JH, Kim HD, Ryu GH |title=Isolation of human Dna2 endonuclease and characterization of its enzymatic properties |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1854–64 |year= 2006 |pmid= 16595799 |doi= 10.1093/nar/gkl102 | pmc=1428795 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Nagase T, Miyajima N, Tanaka A |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=10.1093/dnares/2.1.37 |display-authors=etal|doi-access=free }}

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