DNPEP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.{{cite journal | vauthors = Wilk S, Wilk E, Magnusson RP | title = Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 26 | pages = 15961–70 | date = Jun 1998 | pmid = 9632644 | doi = 10.1074/jbc.273.26.15961 | doi-access = free }}{{cite web | title = Entrez Gene: DNPEP aspartyl aminopeptidase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23549}}
Function
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in the general metabolism of intracellular proteins.
See also
- {{Portal-inline|Biology}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M |author-link30=Huda Zoghbi| title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 |bibcode=2005Natur.437.1173R|s2cid=4427026}}
- {{cite journal | vauthors = Prieto I, Hermoso F, de Gasparo M, Vargas F, Alba F, Segarra AB, Banegas I, Ramírez M | title = Angiotensinase activities in the kidney of renovascular hypertensive rats | journal = Peptides | volume = 24 | issue = 5 | pages = 755–60 | date = May 2003 | pmid = 12895663 | doi = 10.1016/S0196-9781(03)00121-9 | citeseerx = 10.1.1.379.1582 | s2cid = 16379232 }}
- {{cite journal | vauthors = Wilk S, Wilk E, Magnusson RP | title = Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase | journal = Archives of Biochemistry and Biophysics | volume = 407 | issue = 2 | pages = 176–83 | date = Nov 2002 | pmid = 12413488 | doi = 10.1016/S0003-9861(02)00494-0 }}
{{refend}}
External links
- The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M18.002 M18.002]
- [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9ULA0 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Aspartyl aminopeptidase (DNPEP)
{{Proteases}}
{{Enzymes}}
{{gene-2-stub}}