DPF2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.{{cite journal | vauthors = Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL | title = Cerd4, third member of the d4 gene family: expression and organization of genomic locus | journal = Mamm Genome | volume = 12 | issue = 11 | pages = 862–6 |date=Feb 2002 | pmid = 11845289 | doi =10.1007/s00335-001-3039-1 | s2cid = 2149578 }}{{cite web | title = Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5977}}
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
References
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Further reading
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- {{cite journal | vauthors=Gabig TG, Mantel PL, Rosli R, Crean CD |title=Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells |journal=J. Biol. Chem. |volume=269 |issue= 47 |pages= 29515–9 |year= 1994 |doi=10.1016/S0021-9258(18)43910-5 |pmid= 7961935 |doi-access=free }}
- {{cite journal | author=Chestkov AV |title=The d4 gene family in the human genome |journal=Genomics |volume=36 |issue= 1 |pages= 174–7 |year= 1997 |pmid= 8812431 |doi= 10.1006/geno.1996.0440 |name-list-style=vanc| author2=Baka ID | author3=Kost MV | display-authors=3 | last4=Georgiev | first4=Georgy P. | last5=Buchman | first5=Vladimir L. }}
- {{cite journal | author=Guru SC |title=A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus |journal=Genome Res. |volume=7 |issue= 7 |pages= 725–35 |year= 1997 |pmid= 9253601 |doi= 10.1101/gr.7.7.725| pmc=310681 |name-list-style=vanc| author2=Agarwal SK | author3=Manickam P | display-authors=3 | last4=Olufemi | first4=SE | last5=Crabtree | first5=JS | last6=Weisemann | first6=JM | last7=Kester | first7=MB | last8=Kim | first8=YS | last9=Wang | first9=Y }}
- {{cite journal | author=Gabig TG |title=Expression and chromosomal localization of the Requiem gene |journal=Mamm. Genome |volume=9 |issue= 8 |pages= 660–5 |year= 1998 |pmid= 9680388 |doi=10.1007/s003359900840 |name-list-style=vanc| author2=Crean CD | author3=Klenk A | display-authors=3 | last4=Long | first4=Haiyan | last5=Copeland | first5=Neal G. | last6=Gilbert | first6=Debra J. | last7=Jenkins | first7=Nancy A. | last8=Quincey | first8=Danielle | last9=Parente | first9=Fabienne |s2cid=22559464 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |name-list-style=vanc| author2=Bauch A | author3=Ruffner H | display-authors=3 | last4=Angrand | first4=Pierre-Olivier | last5=Bergamini | first5=Giovanna | last6=Croughton | first6=Karen | last7=Cruciat | first7=Cristina | last8=Eberhard | first8=Dirk | last9=Gagneur | first9=Julien |s2cid=11683986 }}
- {{cite journal | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |name-list-style=vanc| author2=Jedrychowski M | author3=Schwartz D | display-authors=3 | last4=Elias | first4=JE | last5=Villén | first5=J | last6=Li | first6=J | last7=Cohn | first7=MA | last8=Cantley | first8=LC | last9=Gygi | first9=SP |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-style=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias |s2cid=7827573 | doi-access=free}}
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External links
- {{MeshName|DPF2+protein,+human}}
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{{Transcription factors}}
Category:Transcription factors
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