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DPP6

{{Short description|Human protein and coding gene}}

{{Infobox_gene}}

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.{{cite journal | vauthors = Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S | title = Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 1 | pages = 197–201 |date=Feb 1992 | pmid = 1729689 | pmc = 48203 | doi =10.1073/pnas.89.1.197 | doi-access = free }}{{cite web | title = Entrez Gene: DPP6 dipeptidyl-peptidase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1804}}

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

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Further reading

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  • {{cite journal | vauthors=Adams MD, Kerlavage AR, Fleischmann RD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf |display-authors=etal}}
  • {{cite journal | vauthors=Yokotani N, Doi K, Wenthold RJ, Wada K |title=Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 1037–9 |year= 1993 |pmid= 8103397 |doi=10.1093/hmg/2.7.1037 |url=https://zenodo.org/record/1234321 }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free }}
  • {{cite journal | vauthors=Kin Y, Misumi Y, Ikehara Y |title=Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. |journal=J. Biochem. |volume=129 |issue= 2 |pages= 289–95 |year= 2001 |pmid= 11173531 |doi= 10.1093/oxfordjournals.jbchem.a002856}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Nadal MS, Ozaita A, Amarillo Y |title=The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. |journal=Neuron |volume=37 |issue= 3 |pages= 449–61 |year= 2003 |pmid= 12575952 |doi=10.1016/S0896-6273(02)01185-6 |s2cid=11494299 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Schmitt-Ulms G, Hansen K, Liu J |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724–31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 |s2cid=36630738 |display-authors=etal}}
  • {{cite journal | vauthors=Strop P, Bankovich AJ, Hansen KC |title=Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. |journal=J. Mol. Biol. |volume=343 |issue= 4 |pages= 1055–65 |year= 2004 |pmid= 15476821 |doi= 10.1016/j.jmb.2004.09.003 |display-authors=etal}}
  • {{cite journal | vauthors=Zagha E, Ozaita A, Chang SY |title=DPP10 modulates Kv4-mediated A-type potassium channels. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18853–61 |year= 2005 |pmid= 15671030 |doi= 10.1074/jbc.M410613200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Radicke S, Cotella D, Graf EM |title=Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. |journal=J. Physiol. |volume=565 |issue= Pt 3 |pages= 751–6 |year= 2005 |pmid= 15890703 |doi= 10.1113/jphysiol.2005.087312 | pmc=1464568 |display-authors=etal}}
  • {{cite journal | vauthors=Ren X, Hayashi Y, Yoshimura N, Takimoto K |title=Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. |journal=Mol. Cell. Neurosci. |volume=29 |issue= 2 |pages= 320–32 |year= 2005 |pmid= 15911355 |doi= 10.1016/j.mcn.2005.02.003 |s2cid=34065803 }}
  • {{cite journal | vauthors=Jerng HH, Kunjilwar K, Pfaffinger PJ |title=Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. |journal=J. Physiol. |volume=568 |issue= Pt 3 |pages= 767–88 |year= 2006 |pmid= 16123112 |doi= 10.1113/jphysiol.2005.087858 | pmc=1464192 }}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B |title=Differential characterization of three alternative spliced isoforms of DPPX. |journal=Brain Res. |volume=1094 |issue= 1 |pages= 1–12 |year= 2006 |pmid= 16764835 |doi= 10.1016/j.brainres.2006.03.106 |s2cid=33513405 }}

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